US 2003/0190715 A1Published application

Novel proteins and nucleic acids encoding same

OwnerWilliam M. Grosse, John P. Alsobrook II +16inventors

InventorsWilliam M. Grosse, John P. Alsobrook II, Denise M. Lepley, Catherine E. Burgess, Vishnu Mishra, Ramesh Kekuda, Li Li, Muralidhara Padigaru, Richard A. Shimkets, Bryan D. Zerhusen, Kimberly A. Spytek, Shlomit R. Edinger, Valerie Gerlach, John R. MacDougall, Isabelle Millet, David J. Stone, Erik Gunther, Karen Ellerman

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Abstract

Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Claims49

Dependent claims

An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:

(a) a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24 and 26;
(b) a variant of a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24 and 26, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of the amino acid residues from the amino acid sequence of said mature form;
(c) an amino acid sequence selected from the group consisting SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24 and 26;
and
(d) a variant of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24 and 26, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence.

6 more elements

An isolated nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of:

(a) a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24 and 26;
(b) a variant of a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24 and 26, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of the amino acid residues from the amino acid sequence of said mature form;
(c) an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24 and 26;
(d) a variant of an amino acid sequence selected from the group consisting SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24 and 26, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence;
(e) a nucleic acid fragment encoding at least a portion of a polypeptide comprising an amino acid sequence chosen from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24 and 26, or a variant of said polypeptide, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence;
and
(f) a nucleic acid molecule comprising the complement of (a), (b), (c), (d) or (e).

9 more elements

Dependencies are inferred from the claim text.

Facts

Application: 09/976,782Filed 12 Oct 2001
Priority: 12 Oct 2000
Published: 9 Oct 2003
Term ends: Not estimatedThe source records don’t support an estimate.

Classification11 codes

C12N 9/12
Transferases: transferring phosphorus containing groups, e.g. kinases
C07K 14/47
From vertebrates: from mammals
C07K 14/4741
Not used: keratin; Cytokeratin
C07K 14/70571
Receptors; Cell surface antigens; Cell surface determinants: for neuromediators, e.g. serotonin receptor, dopamine receptor

Family

Application60/240,113Us provisional application · filed 12 Oct 2000
Application60/240,662Us provisional application · filed 16 Oct 2000
Application60/240,732Us provisional application · filed 16 Oct 2000
Application60/240,625Us provisional application · filed 16 Oct 2000
Application60/240,648Us provisional application · filed 16 Oct 2000
Application60/240,703Us provisional application · filed 16 Oct 2000
Application60/241,190Us provisional application · filed 16 Oct 2000
Application60/240,637Us provisional application · filed 16 Oct 2000
Application60/240,669Us provisional application · filed 16 Oct 2000
Application60/262,455Us provisional application · filed 18 Jan 2001
US 2003/0190715 A1This patent

From the US filing history. Foreign family members aren’t listed.