Regulated gene in the pathophysiology of ischemic stroke
OwnerMehrdad Shamloo, Mirella Gonzalez-Zulueta +1inventors
InventorsMehrdad Shamloo, Mirella Gonzalez-Zulueta, Tadeusz Wieloch
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Abstract
The present invention identifies the K11 gene, whose gene products can be modulated to provide a protective effect against stroke, especially ischemic stroke, epilepsy and neurodegenerative disorders and enhancement of memory function. Further, the invention provides methods for diagnosing or assessing an individual's susceptibility to a stroke. Also provided are therapeutic methods for treating a stroke patient or methods for prophylactically treating an individual susceptible to stroke. Additionally, the invention describes screening methods for identifying agents that can be administered to treat individuals that have suffered a stroke or that are at risk for stroke.
Claims19
An isolated nucleic acid molecule encoding the K11 polypeptide set forth in SEQ ID NO:
- 2 or 4.
An isolated polypeptide comprising the sequence set forth in SEQ ID NO:
- 2 or 4.
A method for developing biologically active agents that modulate activity of K11, the method comprising:
- combining a candidate biologically active agent with any one of:
- (a) the polypeptide as set forth in SEQ ID NO:
- 2;
- 4;
- or 13
- (b) a cell comprising a nucleic acid encoding and expressing a polypeptide as set forth in SEQ ID NO:
- 2;
- 4;
- or 13;
- or
- (c) a non-human transgenic animal model for K11 function comprising one of:
- (i) a knockout of a gene corresponding SEQ ID NO:
- 1, 3 or 13;
- (ii) an exogenous and stably transmitted mammalian gene sequence comprising SEQ ID NO:
- 1, 3 or 13;
- and
- determining the effect of said agent on ischemia induced molecular and cellular changes.
A method for the diagnosis of ischemia, the method comprising:
- determining the upregulation of expression of SEQ ID NO:
- 1, 3 or 13.
An antibody specific for the protein set forth in SEQ ID NO:
- 2 or SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.