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OwnerGlenville Jones, Martin P. Petkovich +3inventors
InventorsGlenville Jones, Martin P. Petkovich, Jay A. White, Heather A. Ramshaw, Wayne A. Stangle
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The present invention relates to a novel human gene encoding a polypeptide that is a member of the cytochrome P450 family. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named cytochrome P450TEC (Thymus Expressed Cytochrome). This invention also relates to P450TEC polypeptides, as well as vectors, host cells, and antibodies directed to P450TEC polypeptides, and the recombinant methods for producing the same. Also provided are therapeutic methods for treating P450TEC-related disorders. The invention further relates to screening methods for identifying agonists and antagonists of P450TEC activity.
An isolated nucleic acid molecule comprising a polynucleotide encoding a cytochrome P450 arachidonic acid metabolizing peptide or functional fragment thereof having a sequence selected from the group consisting of:
A polynucleotide encoding a polypetpide epitope of SEQ ID NO 17 or the cDNA sequence contained in ATCC Deposit No. PTA-1785;
An isolated nucleic acid molecule of consisting of nucleotides 1400-1779 of SEQ ID NO. 16.
An isolated cytochrome P450, arachachidonic acid metabolizing polypeptide or functional fragment thereof comprising an amino acid sequence selected from the group consisting of
The gene corresponding to the cDNA sequence of SEQ ID NO:16.
A method of identifying an activity in a biological assay, wherein the method comprises:
A method of diagnosis of a P450 TEC-related disease or condition or a predisposition to a P450 TEC-related disease or condition comprising detecting a polymorphism in a P450 TEC gene, wherein detection of said polymorphism is indicative of the occurrence of said disease, condition or a predisposition thereto.
A diagnostic kit for identification of polymorphisms in the P450 TEC gene, comprising screening the P450 TEC gene from a human for polymorphisms, wherein detection of said polymorphisms is indicative of the occurrence of a P450 TEC-related disease, condition or a predisposition thereto.
A method of identifying modulators of P450TEC activity in a biological assay, wherein the method comprises:
A method of quantifying the levels of P450TEC in a sample comprising:
Dependencies are inferred from the claim text.