Genes involved in intestinal inflamatory diseases and use thereof
AssigneeFondation Jean Dausset-CEPH
InventorsJean-Pierre Hugot, Gilles Thomas, Mohammed Zouali, Suzanne Lesage, Mathias Chamaillard
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Abstract
The invention concerns genes involved in inflammatory and/or immune diseases and some cancers, in particular intestinal cryptogenic inflammatory diseases, and proteins coded by said genes. The invention also concerns methods for diagnosing inflammatory diseases.
Claims25
A purified or isolated nucleic acid, characterized in that it comprises a nucleic acid sequence chosen from the following group of sequences:
- a) SEQ ID No. 1, SEQ ID No. 3, SEQ ID No. 4 and SEQ ID No. 6;
- b) the complementary sequence or the RNA sequence corresponding to a sequence as defined in a).
A purified or isolated nucleic acid, characterized in that it encodes a polypeptide possessing a continuous fragment of at least 200 amino acids of a protein chosen from SEQ ID No. 2 and SEQ ID No. 5.
An isolated polypeptide, characterized in that it comprises a polypeptide chosen from:
- a) a polypeptide corresponding to SEQ ID No. 2 or SEQ ID No. 5;
- b) a fragment of at least 15 consecutive amino acids of a polypeptide defined in a);
- c) a biologically active fragment of a polypeptide defined in a) or b).
A method of diagnosis and/or of prognostic assessment of an inflammatory and/or immune disease or of a cancer, characterized in that the presence of at least one mutation and/or a deleterious modification of expression of the gene corresponding to SEQ ID No. 1, SEQ ID No. 3, SEQ ID No. 4 or SEQ ID No. 6 is determined, using a biological specimen from a patient, by analyzing all or part of a nucleic acid sequence corresponding to said gene.
Dependencies are inferred from the claim text.