Human kidins220Pc

An isolated polynucleotide comprising,

• a human kidins220Pc polynucleotide sequence having 99% or more nucleotide sequence identity to the polynucleotide sequence set forth in SEQ ID NO 1 along its entire length, which codes without interruption for human kidins220Pc, or a complement thereto, and which has protein binding activity.

An isolated polynucleotide of claim 3 having kinase substrate activity.

An isolated polypeptide which is human kidins220Pc having 99% or more amino acid sequence identity to the amino acid sequence set forth in SEQ ID NO 2, and which has protein binding activity.

A method of detecting polymorphisms in human kidins220Pc comprising:

• comparing the structure of:
• genomic DNA comprising all or part of human kidins220Pc, mRNA comprising all or part of human kidins220Pc, cDNA comprising all or part of human kidins220Pc, or a polypeptide comprising all or part of human kidins220Pc, with the complete structure of human kidins220Pc as set forth in SEQ ID NO 1.

A non-human, transgenic mammal comprising a cell of claim 22.

An antibody which is specific-for:

• an epitope comprising amino acid 136 of SEQ ID NO 2, or a polypeptide consisting essentially of amino acid residues 1138-1184 (SEQ ID,NO 3), 1138-1176(SEQ ID NO 3), 1177-1184 (SEQ ID NO 3), 1138-1194 (SEQ ID NO 4), or 1177-1194 (SEQ ID NO 4).