DPI-6, a putative therapeutic target and biomarker in neuropsychiatric and neurological disorders
OwnerHerath Mudiyanselage Athula Chandrasiri Herath, Rajesh Bhikhu Parekh +2inventors
InventorsHerath Mudiyanselage Athula Chandrasiri Herath, Rajesh Bhikhu Parekh, Christian Rohlff, Thakorhlai Parshotambhai Patel
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Abstract
The present invention provides a protein (DPI-6) identified in CSF, compositions comprising the protein, including vaccines and antibodies which are immunospecific for the protein. The use of the protein in the diagnosis, screening, treatment and prophylaxis of a neurological or neuropsychiatric condition is also provided.
Claims15
A method of screening for and/or diagnosis of a neuropsychiatric and/or neurological condition in a subject, which method comprises the step of detecting and/or quantifying the amount of a polypeptide in a biological sample obtained from said subject, wherein the polypeptide is selected from:
- a) the amino acid sequence shown in FIGS. 1 or 3;
- b) a derivative having one or more amino acid substitutions, deletions or insertions relative to the amino acid sequence shown in FIGS. 1 or 3;
- and
- c) a fragment of a polypeptide as defined in a) or b) above, which is at least ten amino acids long.
A method of screening for and/or diagnosis of a neuropsychiatric and/or neurological condition in a subject, which method comprises the step of detecting and/or quantifying the amount of a nucleic acid in a biological sample obtained from said subject, wherein the nucleic acid molecule:
- a) comprises the RNA sequence shown in FIG. 2 or its DNA equivalent;
- b) has a sequence which is complementary to the sequences of a);
- c) has a sequence which codes for the same polypeptide as the sequences of a) or b);
- d) has a sequence which shows substantial identity with any of those of a), b) and c);
- or
- e) has a sequence which codes for a derivative or fragment of an amino acid molecule shown in FIG. 1.
Dependencies are inferred from the claim text.