Polynucleotide encoding an activated human T-lymphocyte-derived protein related to ubiquitin conjugating enzyme

A substantially purified ubiquitin conjugating (UBC) enzyme polypeptide selected from the group consisting of:

• (a) a ubiquitin conjugating enzyme polypeptide having the amino acid sequence as set forth in SEQ ID NO:2;
• (b) a ubiquitin conjugating enzyme polypeptide comprising an amino acid sequence having at least 80% sequence identity to the sequence set forth in SEQ ID NO:2;
• (c) a polypeptide according to (a), wherein the amino acid sequence differs from SEQ ID NO:2 only by conservative substitutions;
• (d) a polypeptide according to (a), wherein the amino acid sequence has at least 90% sequence identity to the sequence set forth in SEQ ID NO:2;
• (e) an isolated ubiquitin conjugating enzyme polypeptide encoded by the nucleic acid sequence of ATCC Accession No. PTA-3745;
• (f) an isolated polypeptide having the amino acid sequence according to amino acids 2 to 422 of SEQ ID NO:2, wherein said amino acid encode a polypeptide of SEQ ID NO:2 minus the start methionine;
• (g) an isolated polypeptide having the amino acid sequence according to amino acids 1 to 422 of SEQ ID NO:2, wherein said amino acid encode a polypeptide of SEQ ID NO:2 including the start methionine;
• (h) an isolated polypeptide having the transmembrane domain region set forth in SEQ ID NO:17;
• and
• (i) a substantially purified fragment of the ubiquitin conjugating enzyme polypeptide according to any one of (a) to (h).