Hepatitis C virus NS5B truncated protein and methods thereof to identify antiviral compounds
AssigneeSmithKline Beecham Corporation
InventorAlfred M. DelVecchio
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Abstract
The invention provides HCV NS5B polypeptides and DNA (RNA) encoding HCV NS5B polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing HCV NS5B polypeptides to screen for antiviral compounds.
Claims18
An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of:
- (a) a polynucleotide having at least a 95% identity to a polynucleotide encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:4;
- (b) a polynucleotide encoding a polypeptide comprising an amino acid sequence which is at least 95% identical to the amino acid sequence of SEQ ID NO:4;
- and
- (c) a polynucleotide which is complementary to the polynucleotide(s) of (a) or (b).
An isolated polynucleotide comprising the nucleic acid sequence set forth in SEQ ID NO:3.
An isolated polynucleotide which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:4.
A polypeptide comprising an amino acid sequence which is at least 95% identical to the amino acid sequence according to SEQ ID NO:4.
A polypeptide comprising an amino acid sequence as set forth in SEQ ID NO:4.
Dependencies are inferred from the claim text.