US 2003/0190395 A1 · Methods for buffer stabilized aqueous deacylation

Abstract

The present invention relates to novel methods for stabilizing aqueous deacylation, via use of buffers in the production of sucralose. The present invention provides a process for producing sucralose from an acyl-sucralose compound whereby the acyl-sucralose compound is deacylated in the presence of a buffering agent, which stabilizes the pH of the feed mixture and decreases the accumulation of undesired anhydro compounds. Further, the present invention provides a process whereby the acyl-sucralose compound is deacylated directly either prior to or after removal of the tertiary amide reaction vehicle from the neutralized chlorination feed mixture. An aqueous solution of sucralose including salts and other compounds is produced, from which sucralose is recovered by extraction and purified by crystallization.

Claims46

Dependent claims

A process for producing sucralose from a feed mixture comprising an acyl-sucralose compound in an aqueous solution, wherein said process comprises:

(a) adjusting the pH of said feed mixture to a range of about 8.0 to about 12.0;
(b) maintaining said feed mixture at an appropriate temperature for sufficient time to effect conversion of said acyl-sucralose compound into free sucralose;
(c) adding a buffer to said feed mixture in an amount sufficient to stabilize said pH within said range for the duration of said maintaining step;
(d) decreasing said pH of said feed mixture to about 4 to about 8;
and
(e) recovering sucralose from the product of step (d), thereby obtaining a recovered sucralose.

3 more elements

Dependencies are inferred from the claim text.

Methods for buffer stabilized aqueous deacylation

Life of this patent

Methods for buffer stabilized aqueous deacylation

Life of this patent

Abstract

Claims46