Process for preparing oral sustained-release formulation of felodipine
AssigneeStandard Chem. & Pharm. Co., Ltd.
InventorsYea-Sheng Yang, Ya-Ching Changchien
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Abstract
The present invention relates to a process for producing an oral sustained-release pharmaceutical composition of felodipine. The process includes mixing together felodipine with at least an ionic surfactant or hydrophilic polymer, and at least a release-controlling excipient. The pharmaceutical composition of felodipine produced by the process of the present invention possesses the enhanced dissolution rate of the insoluble drug of felodipine, whereas the sustained releasing profile and superior bioavailability of the produced pharmaceutical composition of felodipine are retained.
Claims23
A process for preparing an oral sustained-release formulation of felodipine, comprising mixing felodipine together with at least an ionic surfactant or hydrophilic polymer and at least a release-controlling excipient to form a uniform felodipine mixture,
- wherein the release-controlling excipient is selected from hydrophilic colloid, hydrophobic cellulose and wax.
Dependencies are inferred from the claim text.