Use of nanodispersions in pharmaceutical end formulations
AssigneesCiba Specialty Chemicals Corporation, Vesifact AG
InventorsANDREAS WERNER SUPERSAXO, HANS GEORG WEDER, DIETMAR HUGLIN, JOACHIM FRIEDRICH RODING
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Abstract
A description is given of the use of a nanodispersion, which comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in pharmaceutical end formulations, the nanodispersion being obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (β) adding the liquid obtained in step (α) to the water phase of the pharmaceutical end formulations, steps (α) and (β) being carried out without any additional supply of energy. The nanodispersions used according to this invention are suitable as transport vehicles for pharmaceutical active agents.
Claims27
A method of preparing a pharmaceutic end formulation using a nanodispersion, which comprises
- (a) a membrane-forming molecule,
- (b) a coemulsifier and
- (c) a lipophilic component,
- by
- (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained (so-called nanodispersion prephase), and
- (β) adding the liquid obtained in step (α) to the water phase of the pharmaceutical end formulations, steps (α) and (β) being carried out without any additional supply of energy.
A nanodispersion prephase, which is obtained by mixing the components
- (a) membrane-forming molecule,
- (b) coemulsifier and
- (c) lipophilic component
- until a homogeneous clear liquid is obtained, mixing being carried out in anhydrous medium.
A nanodispersion, which comprises
- (a) a membrane-forming molecule,
- (b) a coemulsifier and
- (c) a lipophilic component,
- which is obtainable by
- (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and
- (β) adding the liquid obtained in step (α) to the water phase, steps (α) and (β) being carried out without additional supply of energy.
Dependencies are inferred from the claim text.