Antimycotic gel with high active substance release

#The present invention relates to a topically applicable antimycotic preparation having high active compound release in the form of a gel preparation which contains at least one antimycotic substance from the hydroxypyridone class and at least one hydrophilic gel-forming agent.

#For the topical treatment of mycoses, especially mycoses of the skin, various preparation forms of hydroxypyridone derivatives such as solutions, ointments and powders are already known. Optimum treatment of dermatomycoses, however, using the preparation forms of hydroxy-pyridones known until now is not unrestrictedly possible for the most diverse reasons.

#Topically applicable liquid preparations in general include clear aqueous or aqueous-alcoholic solutions. They are either painted onto the skin surface or used for washing or baths. In particular, they are used in any skin regions which are covered by dense hair growth, since ointments or powders are not suitable for these areas. Moreover, they are used in those skin areas for which other pharmaceutical forms are not willingly used for cosmetic reasons, e.g. on the face or on highly mobile body sites (e.g. elbows, knee etc.).

#A preparation according to the invention has the following composition: 1 1-Hydroxy-4-methyl-6-(2,4,4-trimethylphenyl)-2(1H)-pyridone 0.50% Hydroxyethylcellulose 1.50% Polyethylene glycol-7 glycerylcocoate 5.00% 1,2-propane glycol 10.00% Isopropyl alcohol 20.00% Demineralized water 63.00%

#A preparation according to the invention has the following composition: 2 1-Hydroxy-4-methyl-6-cyclohexyl-2(1H)pyridone 1.00% Polyacrylic acid polymer (e.g. Carbomer 934 P) 0.70% Sodium hydroxide 0.20% Sodium dioctylsulfosuccinate 0.05% 2-octyldodecanol 7.50% Isopropyl alcohol 25.00% Demineralized water 65.55%

#A preparation according to the invention has the following composition: 3 1-Hydroxy-4-methyl-6-cyclohexyl-2(1H)pyridone 0.50% Polyacrylic acid polymer (e.g. Carbomer 940) 0.50% Sodium hydroxide 0.20% Polyoxyethylene(20)sorbitan monostearate 3.50% Isopropyl myristate 10.00% Ethanol 20.00% Demineralized water 65.30%