Topical application of immixture of ascorbic acid + ascorbic acid compounds for augmenting the synthesis of epidermal ceramides
AssigneeSociete L'Oreal S.A.
InventorsIsabelle Castiel, Corinne Ferraris, Armelle La Valle-Bouchard
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Abstract
Synergistic immixtures of ascorbic acid with at least one monosaccharide ester of ascorbic acid and/or at least one metal salt of phosphorylated ascorbic acid more effectively increase the synthesis of epidermal ceramides in human skin, especially types IV to VII ceramides, as well as improve the barrier function, moisture content and/or suppleness/surface appearance of the skin and which otherwise combat/prevent intrinsic aging thereof and are useful for the treatment of dermatitis.
Claims35
A topically applicable cosmetic/dermatological composition suited for augmenting the synthesis of epidermal ceramides, and/or improving the barrier function of the skin, and/or treating atopic or seborrhoeic dermatitis, and/or improving the suppleness and/or surface appearance of the skin and/or combating or preventing intrinsic aging of the skin, and/or moisturizing the skin, comprising a thus-effective amount of ascorbic acid in immixture with at least one monosaccharide ester of ascorbic acid and/or at least one metal salt of phosphorylated ascorbic acid, said ascorbic acid and monosaccharide ester and/or metal salt being present in a combined synergistically effective epidermal ceramide synthesis augmenting amount, formulated into a topically applicable, physiologically acceptable vehicle, diluent or carrier therefor.
A topically applicable cosmetic composition suited for augmenting the synthesis of epidermal ceramides, and/or improving the barrier function of the skin, and/or treating atopic or seborrhoeic dermatitis, and/or improving the suppleness and/or surface appearance of the skin and/or combating or preventing intrinsic aging of the skin, and/or moisturizing the skin, comprising a thus-effective amount of ascorbic acid, at least one monosaccharide ester of ascorbic acid and at least one metal salt of phosphorylated ascorbic acid, said ascorbic acid, monosaccharide ester and metal salt being present in a combined synergistically effective epidermal ceramide synthesis augmenting amount, formulated into a topically applicable, physiologically acceptable vehicle, diluent or carrier therefor.
A topically applicable cosmetic/dermatological composition suited for augmenting the synthesis of epidermal ceramides, and/or improving the barrier function of the skin, and/or treating atopic or seborrhoeic dermatitis, and/or improving the suppleness and/or surface appearance of the skin and/or combating or preventing intrinsic aging of the skin, and/or moisturizing the skin, comprising ascorbic acid in immixture with at least one monosaccharide ester of ascorbic acid and/or at least one metal salt of phosphorylated ascorbic acid, wherein the amount of ascorbic acid is from 0.0001% to 0.01% by weight of said composition;
- wherein the amount of said at least one monosaccharide ester of ascorbic acid is from 0.001% to 0.1% by weight of said composition and/or the amount of said at least one metal salt of phosphorylated ascorbic acid is from 0.001% to 0.1% by weight of said composition;
- and wherein said ascorbic acid and monosaccharide ester and/or metal salt are present in a combined, synergistically effective epidermal ceramide synthesis augmenting amount;
- formulated into a topically applicable, physiologically acceptable vehicle, diluent or carrier therefor.
A topically applicable cosmetic/dermatological composition suited for augmenting the synthesis of epidermal ceramides, and/or improving the barrier function of the skin, and/or treating atopic or seborrhoeic dermatitis, and/or improving the suppleness and/or surface appearance of the skin and/or combating or preventing intrinsic aging of the skin, and/or moisturizing the skin, comprising ascorbic acid in immixture with at least one monosaccharide ester of ascorbic acid and/or at least one metal salt of phosphorylated ascorbic acid, wherein the amount of ascorbic acid is from 0.0001% to 0.01% by weight of said composition;
- wherein the amount of said at least one monosaccharide ester of ascorbic acid is from 0.01% to 0.1% by weight of said composition and/or the amount of said at least one metal salt of phosphorylated ascorbic acid is from 0.01% to 0.1% by weight of said composition;
- and wherein said ascorbic acid and monosaccharide ester and/or metal salt are present in a combined, synergistically effective epidermal ceramide synthesis augmenting amount;
- formulated into a topically applicable, physiologically acceptable vehicle, diluent or carrier therefor.
A topically applicable cosmetic/dermatological composition suited for augmenting the synthesis of epidermal ceramides, and/or improving the barrier function of the skin, and/or treating atopic or seborrhoeic dermatitis, and/or improving the suppleness and/or surface appearance of the skin and/or combating or preventing intrinsic aging of the skin, and/or moisturizing the skin, comprising ascorbic acid in immixture with ascorbyl glucoside and/or magnesium ascorbyl phosphate, wherein the amount of ascorbic acid is from 0.0001% to 0.01% by weight of said composition;
- wherein the amount of ascorbyl glucoside is from 0.001% to 0.1% by weight of said composition and/or the amount of magnesium ascorbyl phosphate is from 0.001% to 0.1% by weight of said composition;
- and wherein ascorbic acid, ascorbyl glucoside and/or magnesium ascorbyl phosphate are present in a combined synergistically effective epidermal ceramide synthesis augmenting amount;
- formulated into a topically applicable, physiologically acceptable vehicle, diluent or carrier therefor.
A topically applicable cosmetic/dermatological composition suited for augmenting the synthesis of epidermal ceramides, and/or improving the barrier function of the skin, and/or treating atopic or seborrhoeic dermatitis, and/or improving the suppleness and/or surface appearance of the skin and/or combating or preventing intrinsic aging of the skin, and/or moisturizing the skin, comprising ascorbic acid in immixture with ascorbyl glucoside and/or magnesium ascorbyl phosphate, wherein the amount of ascorbic acid is from 0.0001% to 0.01% by weight of said composition;
- wherein the amount of ascorbyl glucoside is from 0.01% to 0.1% by weight of said composition and/or the amount of magnesium ascorbyl phosphate is from 0.01% to 0.1% by weight of said composition;
- and
- wherein ascorbic acid, ascorbyl glucoside and/or magnesium ascorbyl phosphate are present in a combined synergistically effective epidermal ceramide synthesis augmenting amount;
- formulated into a topically applicable, physiologically acceptable vehicle, diluent or carrier therefor.
A topically applicable cosmetic/dermatological composition suited for augmenting the synthesis of epidermal ceramides, and/or improving the barrier function of the skin, and/or treating atopic or seborrhoeic dermatitis, and/or improving the suppleness and/or surface appearance of the skin and/or combating or preventing intrinsic aging of the skin, and/or moisturizing the skin, comprising ascorbic acid in immixture with ascorbyl glucoside and magnesium ascorbyl phosphate, wherein the amount of ascorbic acid is from 0.0001% to 0.01% by weight of said composition;
- wherein the amount of ascorbyl glucoside is from 0.001% to 0.1% by weight of said composition and the amount of magnesium ascorbyl phosphate is from 0.001% to 0.1% by weight of said composition;
- and wherein ascorbic acid, ascorbyl glucoside and magnesium ascorbyl phosphate are present in a combined synergistically effective epidermal ceramide synthesis augmenting amount;
- formulated into a topically applicable, physiologically acceptable vehicle, diluent or carrier therefor.
Dependencies are inferred from the claim text.