Immunostimulant compositions comprising aminoalkyl glucosaminide phosphates and saponins
AssigneeCorixa Corporation
InventorsSally Mossman, Lawrence Evans, Jory R. Baldridge, Jay T. Evans
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Abstract
The invention provides pharmaceutical compositions, particularly vaccine compositions, employing an adjuvant system comprising at least one aminoalkyl glucosaminide phosphate compound and at least one saponin compound. Such compositions synergistically enhance the immune response in a mammal to a co-administered antigen. Also provided are methods of using the compositions in the treatment of various human diseases, including cancer, microbial infections and autoimmune disorders.
Claims97
An immunostimulant composition comprising:
- (a) at least one aminoalkyl glucosaminide phosphate (AGP);
- and
- (b) at least one saponin.
3 The composition of claim 2, wherein X is a group of formula (Ia).
The composition of claim 3, wherein R1, R2 and R3 are each C7-C16 aliphatic acyl groups.
The composition of claim 3, wherein R1, R2 and R3 are each C8-C14 aliphatic acyl groups.
The composition of claim 3, wherein R1, R2 and R3 are each C9-C14 aliphatic acyl groups.
The composition of claim 3, wherein R1, R2 and R3 are each C10-C14 aliphatic acyl groups.
The composition of claim 3, wherein R1, R2 and R3 are each C10-C14 saturated aliphatic acyl groups.
The composition of claim 3, wherein the total of n+m is 0, 1, or 2.
The composition of claim 3, wherein p and q are independemtly 0, 1 or 2.
The composition of claim 3, wherein R6 is selected from hydrogen, hydroxy and carboxy.
The composition of claim 3, wherein R1, R2 and R3 all are n-C13H27CO;
- X and Y are both oxygen;
- n, m, p, and q are each zero;
- R4, R5, R6, R7 and R9 are each hydrogen;
- and R8 is PO3H2.
The composition of claim 3, wherein R1, R2 and R3 all are n-C11H23CO;
- X and Y are both oxygen;
- n, m, and q are each zero;
- p is 1;
- R4, R5, R7 and R9 are each hydrogen;
- R6 is hydroxy;
- and R8 is PO3H2.
The composition of claim 3, wherein the saponin is a quillaja saponin.
The composition of claim 3, wherein the saponin is a saponin-lipophile conjugate.
88 A method of treating a mammal suffering from or susceptible to a pathogenic infection, cancer or an autoimmune disorder comprising administering to the mammal an effective amount of a composition according to claim 2
89 A method of treating a mammal suffering from or susceptible to a pathogenic infection, cancer or an autoimmune disorder comprising administering to the mammal an effective amount of a composition according to claim 30.
Dependencies are inferred from the claim text.