Pharmaceutical compositions
OwnerCalvin Rossinventor
Life of this patent
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Abstract
The present invention relates to compositions and dispensing devices for improved administration of fentanyl and other opioid analgesics, such as alfentanil, carfentanil, remifentanil, sufentanil, buprenorphine, morphine, diamorphine, and the like.
Claims40
A pharmaceutical composition comprising a solution of an opioid analgesic and a propellant, for sublingual aerosol administration.
A pharmaceutical composition as claimed in any of the preceding claims, wherein the solution is substantially free of water.
A pharmaceutical composition as claimed in any of the preceding claims, wherein the propellant is 1,1,1,2-tetrafluoroethane HFC-134a) or 1,1,1,2,3,3,3-heptafluoropropane (HFC-227), or a combination thereof.
A pharmaceutical composition as claimed in any of the preceding claims, further comprising a carrier selected from pharmaceutically acceptable alcohols, polyols, (poly) alkoxy derivatives, fatty acid alkyl esters, polyalkylene glycols, and dimethyl sulphoxide.
A pharmaceutical composition as claimed in any of the preceding claims, further comprising an organic surfactant.
A pharmaceutical composition as claimed in any of the preceding claims, wherein the composition is substantially free of weak organic or strong inorganic acid.
A pharmaceutical composition as claimed in any of the preceding claims, further comprising a flavouring oil, preferably peppermint oil.
A pharmaceutical composition as claimed in any of the preceding claims, comprising a further pharmaceutically active agent.
A device, substantially as hereinbefore described and as shown in the accompanying drawings.
A mouthpiece, substantially as hereinbefore described and as shown in the accompanying drawings.
A housing for a device, substantially as hereinbefore described and as shown in the accompanying drawings.
Dependencies are inferred from the claim text.