Pharaceutical aerosol composition
AssigneeChiesi Farmaceutici S.p.A.
InventorsDavid Lewis, Davis Ganderton, Brian Meakin, Paolo Ventura, Gaetano Brambilla, Raffaella Garzia
Life of this patent
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Abstract
A composition for use in an aerosol inhaler, the composition comprising an active material, a propellant containing a hydrofluoroalkane (HFA), a cosolvent and further comprising a low volatility component to increase the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler, filling of an aerosol container and use of the composition for the administration of active materials by inhalation.
Claims23
A composition for use in an aerosol inhaler, the composition comprising an active material, a propellant containing a hydrofluoroalkane (HFA), a cosolvent and further comprising a low volatility component to increase the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler.
A composition according to any preceding claim, wherein the cosolvent has a vapour pressure at 25° C. not less than 3 kPa.
A composition according to any preceding claim, wherein the cosolvent has a vapour pressure at 25° C. not less than 5 kPa.
A composition according to any preceding claim, wherein the cosolvent is an alcohol.
A composition according to any preceding claim, wherein the low volatility component includes a glycol.
A composition according to any preceding claim, wherein the low volatility component includes oleic acid.
A composition according to any preceding claim, wherein the propellant includes one or more HFAs selected from the group comprising HFA 134a and HFA 227.
A composition according to any preceding claim, wherein the composition includes not more than 20% by weight of the low volatility component.
A composition according to any preceding claim, wherein the composition includes at least 0.2% by weight of the low volatility component.
A composition according to any preceding claim, the composition being such that, on actuation of the aerosol inhaler in use, the MMAD of the aerosol particles is not less than 2 μm.
A composition according to any preceding claim, wherein the composition is in the form of a solution.
Use of a low volatility component in a composition for an aerosol inhaler, the composition comprising an active material, a propellant containing hydrofluoro ≡alkane (HFA) and a cosolvent, to increase the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler.
Method of filling an aerosol inhaler with a composition, the method comprising filling the following components into the inhaler
- (a) one or more active materials,
- (b) one or more low volatility components,
- (c) one or more cosolvents followed by the addition of a propellant containing a hydrofluoroalkane (HFA).
Aerosol particles emitted from an aerosol inhaler containing a composition, the composition comprising an active component, a propellant containing a hydrofluoro≡alkane (HFA), a cosolvent and a low volatility component, wherein the mass median aerodynamic diameter (MMAD) of the aerosol particles is not less than 2 μm.
Dependencies are inferred from the claim text.