Multiple-tumor aberrant growth genes
OwnerJorn Bullerdiek, Willem Jan Marie Van de Ven +2inventors
InventorsJorn Bullerdiek, Willem Jan Marie Van de Ven, Henricus Franciscus Petrus Maria Schoenmakers, Rafael Mols
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Abstract
The invention relates to the multi-tumor aberrant growth gene having the nucleotide sequence of any one of the strands of any one of the members of the High Mobility Group protein genes or LIM protein genes, including modified versions and derivatives thereof. The gene and its derivatives may be used in various diagnostic and therapeutic applications.
Claims35
Multi-tumor Aberrant Growth (MAG) gene having the nucleotide sequence of any one of the strands of any one of the members of the High Mobility Group protein genes or LIM protein genes, including modified versions thereof.
Method of diagnosing cells having a non-physiological proliferative capacity, comprising at least some of the following steps:
- a) taking a biopsy of the cells to be diagnosed;
- b) isolating a suitable MAG gene-related macromolecule therefrom;
- c) analysing the macromolecule thus obtained by comparison with a wildtype reference molecule preferably from the same individual.
Method for isolating other MAG genes based on the existence of a fusion gene, fusion transcript or fusion protein in a tumor cell by using at least a part of a MAG gene for designing molecular tools (probes, primers etc.).
Animal model for the assessment of the utility of compounds or compositions in the treatment of diseases or disorders involving cells having a non-physiological proliferative capacity, which animal is a transgenic animal harbouring a MAG gene in its genome.
Poly- or oligonucleotide probes and primers as disclosed in the description and figures.
Dependencies are inferred from the claim text.