Agglomerated particles for aerosol drug delivery
AssigneeCleveland State University
InventorsAnnanth Annapragada, Rohan Bhavane
Life of this patent
Estimating the term…
Abstract
The invention provides a drug delivery vehicle for inhalation by a patient. The drug delivery vehicle comprises biocompatible particles between 0.1 and 1.0 microns in diameter, that are loaded with one or more drugs and which are crosslinked together to form agglomerates. The agglomerates can also provide for delivery of contrast-enhancing agents for clinical imaging. The invention also provides methods of making the inventive agglomerates, pharmaceutical compositions comprising the agglomerates, and methods for delivering drugs or contrast-enhancing agents to a patient by inhalation of pharmaceutical compositions containing the agglomerates.
Claims20
A drug delivery vehicle exhibiting controlled release of drugs when incubated in a physiological environment, the drug delivery vehicle comprising:
- an agglomerate of at least two biocompatible particles loaded with one or more drugs;
- wherein the biocompatible particles have a plurality of reactive groups associated with the surfaces thereof and are chemically cross-linked to one another to form the agglomerate;
- wherein the biocompatible particles have an average size of between 0.1 and 1.0 microns in diameter;
- and
- wherein the agglomerate is of a size capable of being inhaled by a mammalian subject.
A controlled-release delivery vehicle for delivering one or more contrast-enhancing agents for imaging to a mammalian subject the delivery vehicle, comprising:
- an agglomerate of at least two biocompatible particles loaded with one or more contrast-enhancing agents;
- wherein the biocompatible particles have a plurality of reactive groups associated with the surfaces thereof and are chemically cross-linked to one another to form the agglomerate;
- wherein the biocompatible particles have an average size of between 0.1 and 1.0 microns in diameter;
- and
- wherein the agglomerate is of a size capable of being inhaled by a mammalian subject.
Dependencies are inferred from the claim text.