Powdered mannitol and mannitol-containing compositions
OwnerEugen Schwarz, Karin Maul +1inventors
InventorsEugen Schwarz, Karin Maul, Ahmed Al-Ghazawi
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Abstract
The present invention relates to a process for the production of powdered mannitol with improved flow characteristics for use in inhalation systems, and to mannitol having a particle shape specific for this process. Corresponding active ingredient-containing formulations according to the process according to the invention are also described.
Claims22
Process for the production of powdered free flowing mannitol for use in a powder inhaler, characterized by
- a) producing a solution comprising mannitol in a concentration of from 2 to 70% by weight,
- b) spraying the resulting solution into an ascending stream of air in a spray tower or in a fluidised bed dryer at a temperature of from 20 to 400° C. with the aid of spray nozzles, atomisers or of a multicomponent atomizing nozzle which has at least three concentric flow channels each leading to a slit-like orifice, with each slit orifice for spraying a liquid being flanked on each side by a slit orifice for emergence of a gas,
- c) fluidizing, drying and collecting the powdered product which is formed,
- d) where appropriate recycling a part of the powder which is formed and/or spraying also a solid-containing suspension
- e) using water or suitable organic solvents to produce the solution(s) or suspensions.
Carrier for dry powder inhalation formulations containing mannitol produced by a process according to claims 1 to 12. Carrier according to claims 20 to 21 containing at least one carbohdrate and/or cellulose.
Dependencies are inferred from the claim text.