Engineering fungi for the utilisation of l-arabinose
AssigneeValtion Teknillinen Tutkimuskeskus
InventorsJohn Londesborough, Merja Penttilä, Peter Richard
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Abstract
A fungal microorganism can be engineered by means of genetic engineering to utilise L-arabinose. The genes of the L-arabinose pathway, which were unknown, i.e. L-arabinitol 4-dehydrogenase and L-xylulose reductase, were identified. These genes, together with the known genes of the L-arabinose pathway, form a functional pathway. This pathway can be introduced to a fungus, which is completely or partially lacking this pathway.
Claims15
A genetically modified fungus having an increased ability to utilise L-arabinose, characterised in that it has been transformed with a DNA sequence encoding an L-arabinitol 4-dehydrogenase or a DNA sequence encoding a L-xylulose reductase or both said DNA sequences.
An isolated DNA molecule, characterised in that it comprises a gene coding for an L-arabinitol 4-dehydrogenase having the sequence of SEQ ID NO. 1 or a functionally equivalent variant thereof
An isolated DNA molecule, characterised in that it comprises a gene coding for an L-xylulose reductase having the sequence SEQ ID NO. 2 or a functionally equivalent variant thereof.
Dependencies are inferred from the claim text.