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OwnerDavid L. Clapper, Melvin J. Swanson +3inventors
InventorsDavid L. Clapper, Melvin J. Swanson, Sheau-Ping Hu, Richard A. Amos, Terrence P. Everson
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A polybifunctional reagent having a polymeric backbone, one or more pendent photoreactive moieties, and two or more pendent bioactive groups. The reagent can be activated to form a bulk material or can be brought into contact with the surface of a previously formed biomaterial and activated to form a coating. The pendent bioactive groups function by promoting the attachment of specific molecules or cells to the bulk material or coated surface. Bioactive groups can include proteins, peptides, carbohydrates, nucleic acids and other molecules that are capable of binding noncovalently to specific and complimentary portions of molecules or cells.
A polybifunctional reagent comprising a plurality of molecules each comprising a polymeric backbone bearing (a) one or more pendent photoreactive moieties capable of being activated by exposure to a suitable energy source, and (b) two or more pendent bioactive groups capable of specific, noncovalent interactions with complimentary groups, the reagent being capable, upon activation of the photoreactive moieties, of forming a bulk material or surface coating in order to promote the attraction of such complimentary groups.
A polybifunctional reagent comprising a synthetic polymeric backbone bearing (a) one or more pendent photoreactive moieties in the form of photoactivatable ketones, and (b) two or more pendent bioactive groups selected from the group consisting of proteins, peptides, amino acids, carbohydrates, nucleic acids and other molecules that are capable of binding noncovalently to specific and complimentary portions of molecules or cells.
A method of coating a biomaterial surface, the method comprising the steps of (a) providing a polybifunctional reagent comprising a polymeric backbone bearing (i) one or more pendent photoreactive moieties capable of being activated by exposure to a suitable energy source, and (ii) two or more pendent bioactive groups capable of specific, noncovalent interactions with complimentary groups, (b) contacting the surface with the reagent, and (c) activating the photoreactive moieties in order to crosslink the reagent molecules to themselves and/or to the surface.
A method for forming a bulk biomaterial, the method comprising the steps of (a) providing a polybifunctional reagent comprising a polymeric backbone bearing (i) one or more pendent photoreactive moieties capable of being activated by exposure to a suitable energy source, and (ii) two or more pendent bioactive groups capable of specific, noncovalent interactions with complimentary groups, and (b) activating the reagent to form a bulk biomaterial.
A coated biomaterial surface, comprising the bound residues of an activated polybifunctional reagent that initially comprised a polymeric backbone bearing (a) one or more pendent photoreactive moieties capable of being activated by exposure to a suitable energy source, and (b) two or more pendent bioactive groups capable of specific, noncovalent interactions with complimentary groups.
A bulk material comprising the bound residues of an activated polybifunctional reagent that initially comprised a polymeric backbone bearing (a) one or more pendent photoreactive moieties capable of being activated by exposure to a suitable energy source, and (b) two or more pendent bioactive groups capable of specific, noncovalent interactions with complimentary groups.
Dependencies are inferred from the claim text.