Method for inhibition of viral infection
OwnerJeffrey S. Glenninventor
Life of this patent
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Abstract
The invention is directed to inhibiting viral morphogenesis and viral infection. In particular, it concerns effecting such inhibition by inhibiting the prenylation or post prenylation reactions of a viral or host protein.
Claims20
A method to treat a viral infection in a subject via inhibiting the prenylation or a post-prenylation reaction of a protein contained in the virus infecting said subject, which method comprises administering to said subject an effective amount of an agent selected from the group consisting of
- a peptide that mimics the amino acid sequence of a “CXXX” (SEQ ID NO:
- 1), “XCXX” (SEQ ID NO:
- 3), “XXCX” (SEQ ID NO:
- 4), or “XXXC” (SEQ ID NO:
- 5) box as it occurs in said viral protein,
- an inhibitor of a prenyl transferase,
- an inhibitor of an enzyme included in the pathway of a prenyl lipid synthesis from mevalonate,
- a mimic of a prenyl group,
- an inhibitor of a protease that removes the XXX tripeptide from the CXXX polypeptide following prenylation, a protease that removes the XX dipeptide from the XCXX polypeptide following prenylation, or a protease that removes the X residue from the XXCX polypeptide following prenylation, or a protease that removes a C-terminal domain of the prenylated protein including the entire CXXX box,
- an inhibitor of prenyl cysteine methyltransferase, and
- a combination thereof.
A kit to treat a viral infection in a subject via inhibiting the prenylation or a post-prenylation reaction of a protein contained in the virus infecting said subject, which kit comprises:
- a) an effective amount of an agent selected from the group consisting of
- a peptide that mimics the amino acid sequence of a “CXXX” (SEQ ID NO:
- 1), “XCXX” (SEQ ID NO:
- 3), “XXCX” (SEQ ID NO:
- 4), or “XXXC” (SEQ ID NO:
- 5) box as it occurs in said viral protein,
- an inhibitor of a prenyl transferase,
- an inhibitor of an enzyme included in the pathway of a prenyl lipid synthesis from mevalonate,
- a mimic of a prenyl group,
- an inhibitor of a protease that removes the XXX tripeptide from the CXXX polypeptide following prenylation, a protease that removes the XX dipeptide from the XCXX polypeptide following prenylation, or a protease that removes the X residue from the XXCX polypeptide following prenylation, or a protease that removes a C-terminal domain of the prenylated protein including the entire CXXX box,
- an inhibitor of prenyl cysteine methyltransferase, and
- a combination thereof;
- and
- b) an instruction for using said agent in treating said viral infection in said subject.
A method to treat a viral infection in a subject via inhibiting the prenylation or a post-prenylation reaction of a host protein involved in life cycle of said infecting virus, which method comprises administering to said subject an effective amount of an agent selected from the group consisting of
- a peptide that mimics the amino acid sequence of a “CXXX” (SEQ ID NO:
- 1), “XCXX” (SEQ ID NO:
- 3), “XXCX” (SEQ ID NO:
- 4), or “XXXC” (SEQ ID NO:
- 5) box as it occurs in said viral protein,
- an inhibitor of a prenyl transferase,
- an inhibitor of an enzyme included in the pathway of a prenyl lipid synthesis from mevalonate,
- a mimic of a prenyl group,
- an inhibitor of a protease that removes the XXX tripeptide from the CXXX polypeptide following prenylation, a protease that removes the XX dipeptide from the XCXX polypeptide following prenylation, or a protease that removes the X residue from the XXCX polypeptide following prenylation, or a protease that removes a C-terminal domain of the prenylated protein including the entire CXXX box,
- an inhibitor of prenyl cysteine methyltransferase, and
- a combination thereof.
Dependencies are inferred from the claim text.