Diagnostics and therapeutics for cardiovascular disease
AssigneeInterleukin Genetics, Inc.
InventorsSheila E. Francis, David C. Crossman, Gordon W. Duff, Kenneth S. Kornman, Katherine Stephenson
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Abstract
The kits and methods of the present invention relate to the diagnosis of cardiovascular disorders. In one aspect, the invention discloses a method and a kit for determining whether a subject has a fragile plaque disorder. In one aspect, the invention discloses a method and a kit for determining whether the subject has an occlusive disorder. In one aspect, the invention discloses a method and a kit for determining whether the subject has a restenosis disorder. Other methods of the present invention relate to the selection of therapeutics for a patient with a cardiovascular disease.
Claims40
A method for determining whether a patient has a cardiovascular disorder, comprising:
- detecting a first cardiovascular disorder associated allele in a nucleic acid sample from the patient, wherein detection of the first cardiovascular disorder associated allele indicates that the patient has the cardiovascular disorder.
A kit for determining a presence of a cardiovascular disorder in a patient, comprising:
- a means for detecting an allele of IL-1A(+4845), an allele of IL-1B(+3954), an allele of IL-1B(−511), an allele of IL-1RN(+2018), and an allele in linkage disequilibrium with aforesaid alleles;
- and
- a first primer oligonucleotide that hybridizes 5′ or 3′ to an allele selected from the group consisting of an allele of IL-1A (+4845), an allele of IL-1B (+3954), an allele of IL-1B(−511), an allele of IL-1RN(+2018), and an allele in linkage disequilibrium with aforesaid alleles.
The method for treating a patient, comprising:
- detecting whether the patient has a cardiovascular disorder associated allele,
- diagnosing a cardiovascular disorder,
- selecting a cardiovascular disorder therapeutic, and
- providing the cardiovascular disorder therapeutic to the patient.
Dependencies are inferred from the claim text.