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US 2003/0172393 A1Published application
Non-human transgenic mammal, method for producing same and its use
OwnerHolger Reichardt, Gunther Schutz +2inventors
InventorsHolger Reichardt, Gunther Schutz, Klaus Kastner, Peter Herrlich
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Abstract
The present invention relates to a non-human mammal whose glucocorticoid receptor (GR) is modified as regards its inducing function. Furthermore, this invention concerns a process for the production of such a mammal as well as its use for testing chemicals, pharmaceutical preparations and therapeutic approaches.
Claims10
A non-human mammal whose glucocorticoid receptor (GR) is modified as regards its inducing function, the non-human mammal beingobtainable by a process, comprising the steps of:
- (a) transfection of embryonal stem cells of a non-human mammal with a vector which enables a recombination between the DNA coding for the inducing function of GR, of the embryonal stem cells and a corresponding mutated DNA of the vector,
- (b) isolation of cells stably transfected in (a) and introduction thereof into female animals of a non-human mammal, as well as
- (c) analysis of the offspring obtained in (b) for a GR whose inducing function is modified.
Dependencies are inferred from the claim text.