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AssigneeBoard of Regents, The University of Texas System
InventorsKen Fujise, Edward T.H. Yeh
Estimating the term…
The polypeptide Fortilin (also known as Translationally Controlled Tumour Protein, TCTP) specifically interacts with p53, a tumor suppressor involved in the induction of apoptosis and the normal growth regulation of a cell. Fortilin also specifically binds MCL1 (Myeloid Cell Leukemia 1). Fortilin has the ability to prevent apoptosis, which may be unregulated in hyperproliferative cells. The present invention is directed at compositions and methods involving a Fortilin modulator, which can induce apoptosis, for the prevention, treatment, or diagnosis of hyperproliferative diseases and conditions, including cancer and atherosclerosis. It is directed also at compositions and methods involving Fortilin, which can inhibit apoptosis, for the treatment of diseases and condition characterized by apoptosis, including certain vascular conditions.
A method of inhibiting a hyperproliferative cell comprising providing to the cell an effective amount of a Fortilin inhibitor, wherein the inhibitor reduces Fortilin activity in the cell.
A method of treating a patient with a hyperproliferative disease or condition comprising administering to the patient an amount of a Fortilin inhibitor effective to reduce Fortilin activity, thereby conferring a therapeutic benefit on the subject.
A method of treating a patient with cancer comprising administering to the a subject a Fortilin modulator and a second anti-cancer treatment.
A method of inhibiting apoptosis in a cell comprising providing to the cell a Fortilin polypeptide in an amount effective to inhibit apoptosis in the cell.
A method of inhibiting apoptosis in a cell comprising administering to the cell an expression vector comprising a polynucleotide encoding a Fortilin polypeptide under the transcriptional control of a promoter, wherein expression of the Fortilin polypeptide is at a level effective to inhibit apoptosis in the cell.
A method of identifying a modulator of a Fortilin polypeptide comprising:
A method of diagnosing cancer in a subject suspected of having cancer comprising:
A method of preventing apoptosis in a cell comprising providing to the cell an effective amount of Fortilin polypeptide, wherein the Fortilin polypeptide binds MCL1 in the cell and the cell does not undergo apoptosis mediated by p53.
A method of treating a patient with a spinal cord injury comprising administering to the subject an effective amount Fortilin, wherein a therapeutic benefit is conferred to the subject.
A method of preventing muscle atrophy in a subject comprising administering to the subject an effective amount of Fortilin to inhibit apoptosis in a muscle cell.
A method of treating a patient with myocarditis or acute myocardial infarction comprising administering to a myocyte cell in the subject an effective amount of Fortilin to inhibit apoptosis of the myocyte cell.
Dependencies are inferred from the claim text.