Tissue specific expression of exogenous proteins in transgenic chickens
AssigneeOrigen Therapeutics, Inc.
InventorsLei Zhu, Peggy Winters-Digiacinto, Robert J. Etches
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Abstract
Transgenes encoding exogenous proteins are stably integrated into embryonic stem cells and are present in the somatic tissue of transgenic or chimeric birds. The transgenes encode exogenous proteins and are expressed in any of endodermal, ectodermal, mesodermal, or extra embryonic tissue. Tissue specificity is provided by selecting the content of the transgene accordingly. Transgenic birds whose genome is comprised of trangene derived exogenous DNA express exogenous proteins with tissue specificity, and specifically express exogenous proteins in the tubular gland cells of the oviduct to concentrate exogenous proteins in egg white..
Claims8
A transgenic chicken selectively expressing exogenous protein in tubular gland cells wherein the protein is encoded by a transgene stably integrated into a genome of the chicken and wherein the transgene is comprised at least a portion of a promoter of a gene encoding an egg white protein that is operably linked to DNA encoding the exogenous protein.
Dependencies are inferred from the claim text.