Bioengineered tubular graft prostheses
AssigneeOrganogenesis, Inc.
InventorsGinger A. Abraham, Robert M. Carr JR.
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Abstract
The invention is directed to bioengineered tubular graft prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.
Claims6
A bioremodelable tubular prosthesis comprising a single layer of processed tissue matrix formed into a tube which, when implanted into a mammalian patient, undergoes controlled biodegradation occurring with adequate living cell replacement such that the original implanted prosthesis is remodeled by the patient's living cells.
A bioremodelable tubular prosthesis comprising a first layer of processed tissue matrix formed into a tube wherein opposing edges of the layer overlap to form a bonding region between about 5% to 20% of the circumference of the tube which, when implanted into a mammalian patient patient, undergoes controlled biodegradatoin occurring with adequate living cell replacement such that the original implanted prosthesis is remodeled by the patient's living cells.
A method for producing a bioremodelable prosthetic tube construct comprising two layers of processed tissue matrix wherein the method comprises:
- (a) flagging the processed tissue matrix around a sleeve-covered mandrel by hydrating one edge of the processed tissue matrix and contacting the sleeve-covered mandrel to the hydrated edge of the processed tissue matrix;
- (b) drying the processed tissue matrix to the sleeve-covered mandrel;
- (c) rehydrating the processed tissue matrix with a hydrating agent to form hydrated processed tissue matrix;
- (d) rotating the mandrel twice to wrap the hydrated processed tissue matrix to form two wrapped hydrated layers of processed tissue matrix;
- (e) dehydrating the layers of the processed tissue matrix;
- and
- (f) contacting the layers of the processed tissue matrix with a crosslinking agent to crosslink the collagen.
A method for repairing or replacing a damaged tissue comprising implanting a prosthesis in a ptient comprising a layer of processed tissue matrix formed into a tube which, when when implanted into a mammalian patient, undergoes controlled biodegradation occurring with adequate living cell replacement such that the original implanted prosthesis is remodeled by the patient's living cells.
Dependencies are inferred from the claim text.