Porous synthetic bone graft and method of manufacture thereof
AssigneeOrthogem Limited
InventorWei Jen Lo
Life of this patent
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Abstract
A process for preparing artificial bone is described which comprises: (i) preparing a mixture of a finely divided bio-compatible ceramic powder, an organic binder and a pore-forming agent in an inert liquid to form a body and causing at least some of the pore-forming agent to align along a common axis; (ii) optionally shaping the resulting body; (iii) allowing the pore-forming agent to form a porous structure in the body; (iv) heating the shaped body to a temperature sufficient to fix the porous structure and; (v) further heating the body to eliminate residues of organic binder and pore-forming agent and to fuse it.
Claims27
Process for preparing artificial bone which comprises:
- (i) preparing a mixture of a finely divided bio-compatible ceramic powder, an organic binder and a pore-forming agent in an inert liquid to form a body and causing at least some of the pore-forming agent to align along a common axis,
- (ii) optionally shaping the resulting body,
- (iii) allowing the pore-forming agent to form a porous structure in the body,
- (iv) heating the shaped body to a temperature sufficient to fix the porous structure and
- (v) further heating the body to eliminate residues of organic binder and pore-forming agent and to fuse it.
Process according to any one of the preceding claims in which the organic binder is a carbohydrate powder.
Process according to any one of the preceding claims in which the pore-forming agent is yeast, disodium diphosphate or sodium bicarbonate.
Process according to any one of the preceding claims in which the inert liquid is water.
Process according to any one of the preceding claims wherein a slurry of the ceramic powder is first obtained and the organic binder and pore-forming agent are added thereto.
Process according to any one of the preceding claims wherein the pore-forming agent is aligned in step (i) by extruding the body.
Process according to any one of the preceding claims in which the body is shaped using a mould.
Process according to any one of the preceding claims wherein after step (ii) inert liquid is removed from the body.
Process according to any one of the preceding claims wherein step (iv) is carried out a temperature from 100 to 230° C.
Process according to any one of the preceding claims wherein step (v) is carried out by heating to 400 to 1000° C. at a rate not exceeding 10° C. per minute.
Process according to any one of the preceding claims wherein after step (v) the body is annealed at a temperature up to about 1450° C.
Process according to any one of the preceding claims wherein the product of step (v) is immersed in a ceramic slurry which is then boiled and the resulting body is removed by centrifuge.
Artificial bone whenever prepared by a process as claimed in any one of the preceding claims.
Dependencies are inferred from the claim text.