US 2003/0171711 A1 · Closed-loop drug delivery system

Abstract

A delivery system for a drug or bioactive agent includes an implantable pump and a delivery conduit that may be implanted in an organ or other tissue (e.g., the central or the peripheral nervous system) of a subject. A sensor is also implanted, and a controller unit receives the sensor output and directs drug delivery from within the patient pump accordingly. The sensor directly measures a primary biochemical material or state in the tissue or organ system, and the monitoring unit effects closed loop feedback control of the pump to achieve a desired end. The end may be the regulation of metabolism or maintenance of a stable metabolic or other state, or may be treatment regimen, e.g., by delivery of a dosage level or distribution of a drug in specific brain or nervous an system tissue. The sensed material may be the agent itself, a metabolite, or a related native material, tissue state or condition.

Claims19

Dependent claims

A drug delivery system capable of delivering an effective amount of a drug to a subject, comprising:

a delivery pump having a chamber capable of housing at least one drug;
a delivery conduit connected to the pump and adapted to extend into a tissue site in the subject, the delivery conduit being effective to deliver the drug from a distal end thereof to the tissue site;
a sensor, implantable within a subject, and capable of providing a sensor output signal representative of a sensed biochemical parameter;
and
a control unit in communication with the sensor and the pump, wherein the control unit to receives the sensor output signal and communicates a delivery signal to the pump to deliver the drug at a rate and for a duration effective to achieve a desired biochemical parameter within a predetermined range.

2 more elements

Dependencies are inferred from the claim text.

Closed-loop drug delivery system

Life of this patent

Closed-loop drug delivery system

Life of this patent

Abstract

Claims19