Internal biochemical sensing device

An information analyzer for sensing an analyte detected from within a patient's body, comprising:

• a. an elongated filtering member configured to propagate light and having a cladding layer along its length and having a first end and a second end;
• b. the elongated filtering member further comprising a wavelength specific grating region configured to deflect a portion of the propagated light having the specific wavelength into the cladding layer;
• c. a connector operatively connected to the first end of the elongated filtering member and adapted to receive an optical fiber and form an optical connection therewith;
• d. a light source operatively connected to the second end of the elongated filtering member and configured to direct light therethrough;
• and
• e. a processor operatively connected to the cladding layer for detecting the deflected light.

A method of using a compact and portable biosensing device, comprising:

• a. inserting a biosensing element and a first end of an elongated transmitting member into a patient's body such that the first end of the elongated transmitting member is optically aligned with the biosensing element, and a second end of the elongated transmitting member remains outside of the patient's body;
• b. optically coupling the second end of the elongated transmitting member to a portable information analyzer;
• c. directing light from a light source through an elongated filtering member within the information analyzer and through the elongated transmitting member to the biosensing element;
• d. directing fluorescent energy from the biosensing element and activated by the directed light through the elongated transmitting member and through at least a part of the elongated filtering member;
• e. deflecting at least a portion of the fluorescent energy to a cladding layer adjacent to the elongated filtering member;
• and
• f. detecting the deflected fluorescent energy.

An adaptive system of biosensors for sensing a plurality of analytes, comprising:

• a. a first biosensor device comprising a first biosensing element and a first elongated transmitting member;
• b. a second biosensor device comprising second biosensing element and a second elongated transmitting member;
• c. a first end of each of the first and second elongated transmitting members being optically connectable to a portable information analyzer;
• d. wherein the first biosensing element contains a first biosensing material that is different from a second biosensing material contained within the second biosensing element, and the first and second biosensing materials react with different ones of the plurality of analytes.

A method of manufacturing a compact and portable biosensing device, comprising:

• a. encapsulating a biosensing material within a region substantially adjacent to a first end of an elongated transmitting member by attaching a containment matrix to the first end of the elongated transmitting member such that it surrounds the biosensing material;
• b. providing a connector that will align a second end of the elongated transmitting member with a first end of an elongated filtering member such that they are optically connected;
• c. creating a wavelength specific optical grating in a portion of the elongated filtering member;
• and
• d. connecting a light detector to the elongated filtering member adjacent to the wavelength specific optical grating.

A compact and portable biosensing device for detecting an analyte from within a patient's body, comprising:

• a. a biosensing element for implantation in a patient's body including one or more biosensing materials for selective interaction with an analyte, wherein the binding of the analyte to the biosensing material results in a detectable state change within the biosensing element;
• b. a transmitting member having a first end and a second end and a transmitting member outer surface, and the first end being implanted within a patient's body and in proximity with the biosensing element;
• and
• c. an information analyzer connected to the second end of the transmitting member configured for location outside the patient's body.

A compact and portable biosensing device for detecting an analyte from within a patient's body, comprising:

• a. a biosensing element for implantation in a patient's body including one or more biosensing materials for selective interaction with an analyte, wherein the binding of the analyte to the biosensing material results in a detectable state change within the biosensing element, and wherein the biosensing material is enclosed in a containment matrix permeable to the analyte;
• b. a transmitting member having a first end and a second end and a transmitting member outer surface, wherein at least a portion of the transmitting member outer surface is coated to promote cell adhesion, and the first end being implanted within a patient's body and in contact with the biosensing element;
• and
• c. an information analyzer connected to the second end of the transmitting member configured for location outside the patient's body.

The method of manufacturing a component for use in a biosensing device for detecting one or more analytes, including:

• a. providing a transmitting member having a first end and a second end, the second end being configured for operably coupling to an information analyzer;
• b. applying a biosensing element having one or more biosensing materials to the transmitting member first end;
• and
• c. applying a containment matrix to the transmitting member first end wherein the containment matrix substantially surrounds the biosensing materials and wherein the containment matrix is permeable to an analyte to be detected.