Process for the manufacture of 4-(6-bromohexyloxy)-butylbenzene
AssigneeBoehringer Ingelheim Pharma GmbH & Co. KG
InventorsOliver Meyer, Helmut Heitger
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Abstract
The present invention relates to an improved process for preparing 4-(6-bromohexyloxy)-butylbenzene by reacting 4-phenylbutanol with 1,6-dibromohexane in the presence of a base and a phase transfer catalyst, wherein 4-phenylbutanol in a diluent is metered into a mixture consisting of 1,6-dibromohexane, a base, a phase transfer catalyst and a diluent, and the use of the 4-(6-bromohexyloxy)-butylbenzene thus prepared for producing salmeterol in a method known per se.
Claims16
Improved process for preparing 4-(6-bromohexyloxy)-butylbenzene comprised of the steps of reacting 4-phenylbutanol with 1,6-dibromohexane in the presence of a base and a phase transfer catalyst, wherein the 4-phenylbutanol in a diluent is metered into a mixture comprised of 1,6-dibromohexane, a base, a phase transfer catalyst and a diluent.
Dependencies are inferred from the claim text.