US 2003/0171597 A1Published application

Process for producing optically active alpha-amino acid and optically active alpha-amino acid amine

AssigneeMitsubishi Rayon Co., Ltd.

InventorsOsamu Katoh, Toshitaka Uragaki, Tetsuji Nakamura

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Abstract

The present invention provides a process for efficiently producing an optically active α-amino acid and an optically active α-amino acid amide. After contacting with cells or processed cells thereof having an ability to asymmetrically hydrolyse, a water solvent is substituted with at least one solvent selected from the group consisting of linear, branched, or cyclic alcohol having 3 or more carbon atoms and the optically active α-amino acid is preferentially precipitated from the alcohol solution. The addition of basic compounds, particularly potassium compounds to the alcohol solution containing the optically active α-amino acid amide, which is obtained after the separation of the optically active α-amino acid, enables the purification of the amide without the inclusion of amino acid into amino acid amide. Thus, the amide is subjected to the step of racemization and then recycled.

Claims25

Dependent claims

A process for producing optically active α-amino acid and optically active α-amino acid amide which comprises substituting the water solvent of an aqueous solution containing the optically active α-amino acid and the optically active α-amino acid amide with at least one alcohol selected from the group consisting of linear, branched, or cyclic alcohol having 3 or more carbon atoms, and precipitating the optically active α-amino acid from the alcohol solution, wherein α-amino acid is represented by formula (I):process

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wherein R1 and R2 may be the same or different and represent a hydrogen atom, lower alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, cycloalkyl, phenyl, substituted phenyl, heterocycle, and substituted heterocycle;
and α-amino acid amide is represented by formula (II):
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wherein R1 and R2 may be the same or different and represent a hydrogen atom, lower alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, cycloalkyl, phenyl, substituted phenyl, heterocycle, and substituted heterocycle.

2 more elements

Dependencies are inferred from the claim text.