Urethane derivatives

Compounds of the formula I

• 16
• in which
• R is CN, CH2NH2, —NH—C(═NH)—NH2, —CO—N═C(NH2)2, —C(═NH)—NH2, which may also be monosubstituted by Ar′, OH, O—COA, O—COAr, OCOOA, OCOO(CH2)nN(A)2, —COO(CH2)nNA2, OCOO(CH2)mHet, COO—(CH2)m-Het, CO—C(A)2-R3, COOA, COSA, COSAr, COOAr, COOAr′, COA, COAr, COAr′ or by a conventional amino-protecting group
• 17
• R1 is R4 Ar, Ar′ or X,
• R2 is phenyl which is monosubstituted by SA, SOA, SO2A, SONHA, SO2NHA, CF3, COOA, CH2NHA, CN or OA,
• R3 is CHal3, OCOA or
• 18
• R4 is alkyl having 1-20 carbon atoms in which one or two CH2 groups may be replaced by O or S atoms and/or by —CH═CH— groups and/or 1-7 H atoms may be replaced by F,
• A is H or alkyl having 1-20 carbon atoms,
• A′ is alkyl having 1-10 carbon atoms,
• Ar is phenyl or naphthyl, each of which is unsubstituted or monosubstituted, disubstituted or trisubstituted by A′, OH, OA′, NH2, NHA′, NA′2, NO2, CF3, CN, Hal, NHCOA, COOA, CONH2, CONHA′, CONA′2, SA, SOA, SO2A, SO2NH2, SO2NHA′ or SO2NA′2,
• Ar′ is (CH2)n—Ar,
• Het is a monocyclic or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which may be unsubstituted or monosubstituted, disubstituted or trisubstituted by A′, OA′, NH2, NHA′, NA′2, NO2, CN, Hal, NHCOA′, NHSO2A′, COOA, CONH2, CONHA′, CONA′2, COA, SO2NH2, SA′, SOA′, SO2A′ and/or carbonyl oxygen,
• X is (CH2)nY,
• Y is COOA or
• 19
• Hal is F, Cl, Br or I,
• n is 1, 2, 3, 4, 5 or 6, and
• m is 0 or 1,
• and their pharmaceutically tolerated salts and solvates.