Multivalently interactive molecular assembly, capturing agent, drug carrier, calcium chelating agent, and drug enhancer
OwnerNobuhiko Yui, Atsushi Maruyama +1inventors
InventorsNobuhiko Yui, Atsushi Maruyama, Tooru Ooya
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Abstract
A multivalently interactive molecular assembly having a plurality of functional groups or ligands, in which a ratio between Rh and Rg expressed as Rh/Rg is 1.0 or less. Here, Rh is a hydrodynamic radius calculated from dynamic light scattering (DLS) assay performed in aqueous solution; and Rg is a radius of gyration determined based on the Zimm plot generated using data obtained by static light scattering (SLS) assay.
Claims20
A multivalently interactive molecular assembly comprising a plurality of at least one of functional groups and ligands,
- wherein a ratio between Rh and Rg which is expressed by Rh/Rg is 1.0 or less;
- (where Rh is a hydrodynamic radius calculated from dynamic light scattering (DLS) assay performed in aqueous solution;
- and Rg is a radius of gyration determined based on the Zimm plot generated using data obtained by static light scattering (SLS) assay).
A multivalently interactive molecular assembly comprising a plurality of at least one of functional groups and ligands,
- wherein a diffusion constant D calculated from a dynamic light scattering assay performed in aqueous solution increases as scattering vector constant K increases.
A multivalently interactive molecular assembly comprising:
- a plurality of cyclic molecules;
- a linear molecule which threads through the cyclic molecules to hold the cyclic molecules together;
- and
- bulky substituents capping both ends of the linear molecule;
- wherein at least two of the plurality of cyclic molecules are substituted with at least one of a functional group and a ligand.
A multivalently interactive molecular assembly according to claim 12, wherein the functional group containing a caboxyl group at an end thereof is a carboxyalkoxycarbonyl group.
A multivalently interactive molecular assembly comprising:
- a plurality of cyclodextrin molecules;
- a linear molecule which threads through the plurality of cyclodextrin molecules to hold the plurality of cyclodextrin molecules together;
- and
- bulky substituents capping both ends of the linear molecule;
- wherein a peak area of C6 primary hydroxyl group, C2 secondary hydroxyl group and C3 secondary hydroxyl group in at least two of the cyclodextrin molecules are reduced by 10 to 95% than a peak area of the corresponding hydroxyl group in a cyclodextrin with no substituents, as determined by a two-dimensional 1H-NMR spectroscopy.
A capturing agent comprising at least a multivalently interactive molecular assembly which can capture an object of interest,
- wherein the multivalently interactive molecular assembly comprises:
- a plurality of cyclic molecules;
- a linear molecule which threads through the cyclic molecules to hold the cyclic molecules together;
- and
- bulky substituents capping both ends of the linear molecule;
- wherein at least two of the plurality of cyclic molecules are substituted with one of a functional group and a ligand.
A drug carrier which can be bonded to a drug comprising at least a multivalently interactive molecular assembly,
- wherein the multivalently interactive molecular assembly comprises:
- a plurality of cyclic molecules;
- a linear molecule which threads through the cyclic molecules to hold the cyclic molecules together;
- and
- bulky substituents capping both ends of the linear molecule;
- wherein at least two of the plurality of cyclic molecules are substituted with one of a functional group and a ligand.
A calcium chelating agent which can chelate calcium comprising at least a multivalently interactive molecular assembly,
- wherein the multivalently interactive molecular assembly comprises:
- a plurality of cyclic molecules;
- a linear molecule which threads through the cyclic molecules to hold the cyclic molecules together;
- and
- bulky substituents capping both ends of the linear molecule;
- wherein at least two of the plurality of cyclic molecules are substituted with a functional group containing caboxyl group at an end thereof.
A drug enhancer for enhancing efficacy of the drug comprising at least a multivalently interactive molecular assembly,
- wherein the multivalently interactive molecular assembly comprises:
- a plurality of cyclic molecules;
- a linear molecule which threads through the cyclic molecules to hold the cyclic molecules together;
- and
- bulky substituents capping both ends of the linear molecule;
- wherein at least two of the plurality of cyclic molecules are substituted with a functional group containing caboxyl group at an end thereof.
Polyrotaxane which can be used in a multivalently interactive molecular assembly,
- wherein the multivalently interactive molecular assembly comprises:
- a plurality of cyclic molecules;
- a linear molecule which threads through the cyclic molecules to hold the cyclic molecules together;
- and
- bulky substituents capping both ends of the linear molecule;
- wherein at least two of the plurality of cyclic molecules are substituted with one of functional groups and ligands.
Dependencies are inferred from the claim text.