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US 2003/0171564 A1Published application
Novel argS
AssigneeSmithKline Beecham Corporation
InventorElizabeth Jane Lawlor
Life of this patent
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Abstract
The invention provides argS polypeptides and DNA (RNA) encoding argS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing argS polypeptides to screen for antibacterial compounds.
Claims20
An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of:
- (a) a polynucleotide having at least a 70% identity to a polynucleotide encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:2;
- (b) a polynucleotide having at least a 70% identity to a polynucleotide encoding the same mature polypeptide expressed by the argS gene contained in the Streptococcus pneumoniae of the deposited strain;
- (c) a polynucleotide encoding a polypeptide comprising an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID NO:2;
- (d) a polynucleotide which is complementary to the polynucleotide of (a), (b) or (c);
- and
- (e) a polynucleotide comprising at least 15 sequential bases of the polynucleotide of (a), (b), (c) or (d).
3 more elements
A polypeptide comprising an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID NO:2.
A polypeptide comprising an amino acid sequence as set forth in SEQ ID NO:2.
Dependencies are inferred from the claim text.