Novel serine-threonine kinase gene
AssigneeChugai Research Institute for Molecular Medicine, Inc., a Japanese corporation
InventorsJun-Ichi Nezu, Asuka Oku
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Abstract
A novel gene having the consensus sequence of a serine-threonine kinase active site has been isolated by the suppression subtractive hybridization method which comprised of preparing a library of genes expressed specifically in fetal livers and isolating clones from this library at random. This gene presumably participates in cell growth control because it is highly expressed, especially in actively growing cells, and exhibits a significant homology with a vaccinia virus B1R kinase gene. Thus, it can be utilized as a target for developing cell growth inhibitors or antitumor agents.
Claims11
A protein having the amino acid sequence of SEQ ID NO:
- 2, or a protein having the same amino acid sequence where one or more amino acids are added, deleted, or substituted and having serine-threonine kinase activity.
A protein having the amino acid sequence of SEQ ID NO:
- 4, or a protein having the same amino acid sequence where one or more amino acids are added, deleted, or substituted and having serine-threonine kinase activity.
A protein encoded by a DNA sequence that hybridizes with the DNA sequence of SEQ ID NO:
- 1 or its complementary sequence and having serine-threonine kinase activity.
A protein encoded by a DNA sequence that hybridizes with the DNA sequence of SEQ ID NO:
- 3 or its complementary sequence and having serine-threonine kinase activity.
Dependencies are inferred from the claim text.