Chimeric antibody fusion proteins for the recruitment and stimulation of an antitumor immune response
OwnerJoseph D. Rosenblatt, Pia Challita-Eid +3inventors
InventorsJOSEPH D. ROSENBLATT, PIA CHALLITA-EID, SHERIE MORRISON, CAMILLE N. ABBOUD, SEUNG-UON SHIN
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Abstract
The present invention relates to chimeric molecules for the stimulation of an anti-tumor immune response to facilitate immune eradication of breast, ovarian and other cancer cells. The chimeric molecules include a binding region which specifically binds to a tumor specific antigen and a chemokine and/or costimulatory ligand. The invention further provides methods for inducing a tumor specific immune response and compositions which can be administered to mammals.
Claims76
A chimeric molecule suitable for stimulating a tumor specific immune response comprising:
- a binding domain capable of specifically binding to a tumor cell associated antigen, and
- a chemokine or active fragment thereof, which is associated with the binding domain such that the binding domain remains capable of binding to the tumor cell associated antigen and the chemokine retains activity.
A chimeric molecule suitable for stimulating a tumor specific immune response, comprising:
- a binding domain capable of binding to a tumor cell associated antigen, and
- a costimulatory ligand or active fragment thereof, which is associated with the binding domain such that the binding domain remains capable of binding to the tumor cell associated antigen and the costimulatory ligand retains activity.
A method for stimulating a tumor specific immune response comprising:
- contacting the tumor cells in a mammal with the a first chimeric molecule comprising a binding domain capable of binding to a tumor cell associated antigen and a chemokine or active fragment thereof and a second chimeric molecule comprising a binding domain capable of binding to a tumor cell associated antigen and a cost mulatory ligand or active fragment thereof under conditions effective to stimulate an immune response.
A composition for stimulating a tumor specific immune response comprising:
- a chimeric molecule comprising a binding domain capable of binding to a tumor cell associated antigen and a chemokine or active fragment thereof;
- a chimeric molecule comprising a binding domain capable of binding to a tumor cell associated antigen and a costimulatory ligand or active fragment thereof;
- and
- a pharmaceutically-acceptable carrier.
A chimeric molecule suitable for stimulating a tumor specific immune response, comprising:
- a binding domain capable of specifically binding to a tumor cell associated antigen, and
- two or more T-cell effectors selected from the group comprising a chemokine or active fragment thereof, a cytokine or active fragment thereof, and a costimulatory molecule or active fragment thereof, which are associated with the binding domain such that the binding domain remains capable of binding the tumor cell associated antigen and the T-cell effectors retain activity.
Dependencies are inferred from the claim text.