Novel Protein
OwnerDiane Joan Cousens, Diane Michele Ignar +2inventors
InventorsDiane Joan Cousens, Diane Michele Ignar, Philippe Sanseau, Filippo Volpe
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Abstract
A method for in a the identification of a compound which modulates leukotriene B4 like (LTRGW1) receptor activity comprises contacting an LTRGW1 polypeptide comprising) The amino acid sequence of SEQ ID #2, or ii) A variant of (i) which is capable of binding leukotrienes: or iii) A fragment of (i) or (ii) which is capable of binding leukotrienes. Additionally. LTRGW1 has been determined to enhance the response of the leukotriene B4 Receptor (BLTR) to LTB4. Hence LTRGW1 may be used in methods to indentify compounds which modulate BLTR receptor activity.
Claims26
A method for the identification of a compound which modulates leukotriene B4 like (LTRGW1) receptor activity, which method comprises contacting an LTRGW1 polypeptide comprising:
- i) The amino acid sequence of SEQ ID #2, or
- ii) A variant of (i) which is capable of binding leukotrienes;
- or
- iii) A fragment of (i) or (ii) which is capable of binding leukotrienes.
- with a test compound in the presence of a leukotriene such as LTB4, LTD4, LTE4, LTC4, and LTT4.
A method according to any preceeding claim wherein the LTRGW1 polypeptide is expressed in a cell.
A method of treating a patient with a respiratory disorder, said method comprising the administration of a therapeutically effective amount of an antagonist of LTRGW1
A method of treating a respiratory disorder, said method comprising the administration to a patient of a therapeutically effective amount of a substance that downregulates the interaction between LTRGW1 and BLTR, hence decreasing the response of BLTR to its ligand.
Use of a therapeutically effective amount of an antagonist of LTRGW1 in the manufacture of a medicament for the treatment or prophylaxis of respiratory diseases.
Use of an effective amount of a substance that downregulates the interaction between LTRGW1 and BLTR in the manufacture of a medicament for the treatment or prophylaxis of respiratory disorders.
Dependencies are inferred from the claim text.