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US 2003/0171539 A1Published application
Anti-heparin peptides
AssigneeDiagnostica Stago
InventorsGerard Quentin, Florence Laur
Life of this patent
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Abstract
The invention concerns a compound exhibiting an anti-heparin activity, of formula Z Bm ! (AXA)x Bn ! (AXA)y Bo (AXA)z Bp, the diagnostic reagents comprising it and the use of said compound in an in vitro diagnostic test of a medicine for anti-heparin activity.
Claims20
A compound exhibiting anti-heparin activity, of general formula 1:
- Z-Bm-(AXA)x-Bn-(AXA)y-Bo-(AXA)z-Bp
- in which
- *Z has the general formula:
- 17
- with
- Cy=-covalent bond
- —CH2—
- —CO—
- —CO—S—
- —(CH2)n—X—
- with 1≦n≦2 and X=O—, S—,
- 18
- with
- Cx=-covalent bond
- —(CH2)n—, 1≦n≦5
- or
- 19
- with R1=—OH, —NH2
- *B represents a basic amino acid;
- m, n, o and p represent, independently of one another, an integer of between 2 and 4.
- *AXA represents a hydrocarbon-based chain corresponding to the formula:
- —NH—(CH2)n—CO—, n being an integer of between 2 and 6;
- x, y and z represent, independently of one another, an integer of between 1 and 6.
20 more elements
Dependencies are inferred from the claim text.