Novel thioether derivatives, their method for production and use

A thio-compound represented by the following structure,

• 59
• , wherein ring A is a ring represented by Formula 5,
• 60
• which has each of the substituent B, substituent C and substituent D at the positions denoted with a bond, and may be substituted at the positions where no bond is attached;
• substituent B stands for —S(O)nR1,
• , wherein n stands for an integer of 0-2, and R1 stands for a substituent;
• substituent C stands for —X1R2,
• , wherein X1 stands for a intervening group, and R2 stands for a substituent;
• and
• substituent D stands for a substituent bonded to the ring A through a carbon atom.

A compound represented by the following structure and a salt thereof,

• 61
• , wherein each of R1 and R2 stands for
• (1) an alkali metal such as sodium and potassium and so on,
• (2) a hydrogen atom,
• (3) an alkyl group which may be substituted with a fluorine atom, a chlorine atom, a bromine atom, an alkoxy group or a thioalkoxy group, and so on,
• (4) a phenyl group which may be substituted with the aforementioned substituent or substituents, or
• (5) an aralkyl group which may be substituted with the aforementioned substituent or substituents,
• (6) a disubstituted carbamoyl or thiocarbamoyl group represented by the following structure,
• 62
• , wherein R7 stands for
• (1) an alkyl group which may be substituted with a halogen atom such as a fluorine atom, a chlorine atom and a bromine atom,
• (2) a phenyl group which may be substituted with aforementioned substituent or substituents, or
• (3) an aralkyl group which may be substituted with aforementioned substituent or substituents,
• Z stands for an oxygen atom or a sulfur atom,
• n stands for an integer of 0 to 2,
• X stands for a methylene group, a dimethylmethylene group, an oxygen atom, a sulfur atom, a sulfinyl group or a sulfonyl group,
• Each of R3 and R4 stands for (1) a hydrogen atom, (2) an alkyl group which may be substituted with a halogen atom such as a fluorine atom, a chlorine atom and a bromine atom, and so on, (3) a phenyl group which may be substituted with aforementioned substituent or substituents, or (4) an aralkyl group which may be substituted with aforementioned substituent or substituents, or R3 and R4 may be combined to form a methylene group, a keto group or a thioketo group, or R3, R4 and R5 taken together with the carbon atom to which they are attached may form a cyano group,
• R5 stands for (1) a hydroxyl group, (2) a mercapto group, (3) an amino group, (4) a formyl group, (5) an alkyl group which may be substituted with a halogen atom such as a fluorine atom, a chlorine atom, a bromine atom, and so on, (6) an alkoxy group which may be substituted with aforementioned substituent or substituents, (7) a thioalkoxy group which may be substituted with aforementioned substituent or substituents, (8) a phenyl group which may be substituted with aforementioned substituent or substituents, (9) an aralkyl group which may be substituted with aforementioned substituent or substituents,
• R6 means a hydroxyl group, an alkyl group, an alkoxy group, an alkylthio group, a nitro group, a cyano group, a dimethylamino group, or a diethylammino group.