Modified polymeric shaped body, method for producing the same and use thereof
AssigneeMembrana GmbH
InventorsHorst Dieter Lemke, Arne Gehlen
Life of this patent
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Abstract
AGE precursors can be removed from blood, plasma or PBS buffer using a modified polymeric shaped body that can be produced by reaction of diaminoguanidine and/or triaminoguanidine with a starting polymeric shaped body carrying R—X residues, where R is an alkylene group that may or may not be substituted with a hydroxyl group and contains from 1 to 3 carbon atoms, and X is a group that is substituted during the reaction by diaminoguanidine and/or triaminoguanidine, or with a starting polymeric shaped body carrying residues Y, on to which diaminoguanidine and/or triaminoguanidine are added during the reaction.
Claims23
A modified polymeric shaped body that can be produced by reacting diaminoguanidine and/or triaminoguanidine with a starting polymeric shaped body carrying R—X residues, where R is an alkylene group that may or may not be substituted with a hydroxyl group and contains from 1 to 3 carbon atoms, and X is a group that is substituted during the reaction by diaminoguanidine and/or triaminoguanidine, or with a starting polymeric shaped body carrying residues Y, on to which diaminoguanidine and/or triaminoguanidine are added during the reaction.
Method for producing a modified polymeric shaped body comprising the steps a) introduction into a polymer of R—X residues, where R is an alkylene group that may or may not be substituted with a hydroxyl group and contains from 1 to 3 carbon atoms and X is a halogen atom, and production of a starting polymeric shaped body from the polymer containing the R—X residues, or introduction of R—X residues, where R—X has the same meaning as above, into a starting polymeric shaped body or introduction of a residue Y, to which diaminoguanidine and/or triaminoguanidine can be added, into a starting polymeric shaped body and b) reaction of the starting polymeric shaped body containing the R—X residues or the residue Y with diaminoguanidine and/or triaminoguanidine to obtain the modified polymeric shaped body.
Dependencies are inferred from the claim text.