Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxyltilbenes and novel stilbene derivatives and analogues
OwnerGenhui Chen, John M. Webster +3inventors
InventorsGenhui Chen, John M. Webster, Jianxiong Li, Kaiji Hu, Jiang Zhu
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Abstract
Disclosed herein are compositions containing hydroxylstilbenes or their derivatives or analogues. The compositions are useful to inhibit protein kinease, and for the treatment of inflammatory diseases, including psoriasis, multiple sclerosis, rhumatoid arthritis, restinosis, inflammatory bowel disease, and inflammatory lung disease. They are also useful to treat surgical adhesions and graft rejection. Novel derivatives and analogues are also disclosed.
Claims16
A compound of the formula
- 7
- wherein
- R is selected from the group consisting of substituted and unsubstituted alkyl with carbon between 1 to 18, substituted and unsubstituted alkenyl with carbon between 1 to 18, substituted and unsubstituted cyclic alkyl with carbon between 1 to 18, substituted and unsubstituted aryl, substituted and unsubstituted alkynyl with carbon between 1 to 18, halogen, alkoxy with carbon between 1 to 18, acyl group with carbon between 1 to 18, allylsulfoxy with carbon between 1 to 18, alkylsulfonyl with carbon between 1 to 18, alkylthiol with carbon between 1 to 18, hydroxy, thiol, substituted and unsubstituted animo groups,
- wherein X is selected from the group consisting of substituted and unsubstituted alkyl with carbon between 1 to 18, substituted and unsubstituted alkenyl with carbon between 1 to 18, substituted and unsubstituted cyclic alkyl with carbon between 1 to 18, substituted and unsubstituted aryl, substituted and unsubstituted alkynyl with carbon between 1 to 18, substituted and unsubstituted amino group, nitro, carboxy, acyloxy with carbon between 1 to 18, alkoxy with carbon between 1 to 18, hydroxy, halogen, acyl group with carbon between 1 to 18, alkylsulfoxy with carbon between 1 to 18, alkylsulfonyl with carbon between 1 to 18, alkylthiol with carbon between 1 to 18, thiol and heterocyclic group;
- n is 0-5;
- R1 and R2 are selected from the group of acyl with carbon between 1 to 18, hydrogen and alkyl groups with carbon between 1 to 18.
A pharmaceutical composition comprising an effective amount of a compound of the formula I or II:
- 8
- wherein
- R is selected from the group consisting of hydrogen (in the case of formula II only), substituted and unsubstituted alkyl with carbon between 1 to 18, substituted and unsubstituted alkenyl with carbon between 1 to 18, substituted and unsubstituted cyclic alkyl with carbon between 1 to 18, substituted and unsubstituted aryl, substituted and unsubstituted alkynyl with carbon between 1 to 18, halogen, alkoxy with carbon between 1 to 18, acyl group with carbon between 1 to 18, alkylsulfoxy with carbon between 1 to 18, alkylsulfonyl with carbon between 1 to 18, alkylthiol with carbon between 1 to 18, hydroxy, thiol, substituted and unsubstituted amino groups,
- wherein X is selected from the group consisting of substituted and unsubstituted alkyl with carbon between 1 to 18, substituted and unsubstituted alkenyl with carbon between 1 to 18, substituted and unsubstituted cyclic alkyl with carbon between 1 to 18, substituted and unsubstituted aryl, substituted and unsubstituted alkynyl with carbon between 1 to 18, substituted and unsubstituted amino group, nitro, carboxy;
- acyloxy with carbon between 1 to 18, alkoxy with carbon between 1 to 18, hydroxy, halogen, acyl group with carbon between 1 to 18, alkylsulfoxy with carbon between 1 to 18, alkylsulfonyl with carbon between 1 to 18, alkylthiol with carbon between 1 to 18, thiol and heterocyclic group;
- n is 0-5,
- R1 and R2 are selected from the group of acyl with carbon between 1 to 18, hydrogen and alkyl groups with carbon between 1 to 18;
- or pharmaceutically acceptable salts thereof.
A method of inhibiting protein kinase, comprising treating a subject with the compound of formula I or II as defined in claims 34 or a pharmaceutically acceptable salts thereof
Dependencies are inferred from the claim text.