Combination therapy employing ileal bile acid transport inhibiting benzothiepiens and HMG Co-A reductase inhibitors
AssigneeG.D. Searle & Co.
InventorsBradley T. Keller, Kevin C. Glenn, Robert E. Manning
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Abstract
Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals. Also provided are compositions and methods for combination therapy employing ileal bile acid transport inhibitors and HMG Co-A reductase inhibitors for the treatment of hyperlipidemic conditions.
Claims6
A composition, comprising an ileal bile acid transport inhibitor and an HMG Co-A reductase inhibitor.
A pharmaceutical composition, comprising:
- a first amount of an ileal bile acid transport inhibitor, and
- a second amount of an HMG Co-A reductase inhibitor,
- wherein said first and second amounts of said inhibitors together comprise an anti-hyperlipidemic condition effective amount of said inhibitors, and
- a pharmaceutically acceptable carrier.
A combination therapy method for the prophylaxis or treatment of a hyperlipidemic condition in a mammal, comprising:
- administering to said patient a first amount of an ileal bile acid transport inhibitor, and
- administering to said patient a second amount of an HMG Co-A reductase inhibitor,
- wherein said first and second amounts of said inhibitors together comprise an anti-hyperlipidemic condition effective amount of said inhibitors.
Dependencies are inferred from the claim text.