HIV protease inhibitors

A compound of Formula I or its pharmaceutically acceptable salts

• 143
• wherein:
• R1 is H, a straight or branched alkyl of 1 to 6 carbons or a carbocycle of 3 to 6 carbons;
• R2 is H, a straight or branched alkyl of 1 to 5 carbons or a carbocycle of 3 to 6 carbons;
• R3 is H, [C(R9)2]nOR, [C(R9)2]nN(R)2, [C(R9)2]nN(R9)COR, [C(R9)2]nCO2R, [C(R9)2]n(O)COR, [C(R9)2]nCON(R)2, [C(R9)2]nOC(O)N(R)2, [C(R9)2R], [C(R9)2]nN(R9)CON(R)2, [C(R9)2]nN(R9)CO2R, [C(R9)2]nOSO2N(R)2, [C(R9)2]nN(R9)SO2OR, [C(R9)2]nN(R9)SO2N(R)2, [C(R9)2]nOSO2R, [C(R9)2]nN(R9)SO2R, [C(R9)2]nSOpR, [C(R9)2]nN(R9)CSN(R)2, [C(R9)2]nN(R9)C(═NR9)N(R)2, [C(R9)2]nSO2N(R)2, [C(R9)2]nC(NR9)N(R)2, [C(R9)2]nCOR, O[C(R9)2]mOR, N(R)[C(R9)2]mOR, F, Cl, Br, CF3, CN, or ═O when Ar is Het;
• R4, R5, and R6 are independently H, a straight or branched alkyl of 1 to 6 carbons, a cycloalkyl of 3 to 6 carbons, [C(R9)2]nOR, [C(R9)2]nN(R)2, F, Cl, Br, CN, CF3, ═O when Ar is Het;
• [C(R9)2]nN(R9)COR, [C(R9)2]nSOpR, [C(R9)2]nR, [C(R9)2]n(O)COR, O[C(R9)2]mOR, N(R)[C(R9)2]mOR, [C(R9)2]nN(R9)CON(R)2, [C(R9)2]n(O)CON(R)2, [C(R9)2]nNR9CO2R, [C(R9)2]nCOR [C(R9)2]nCO2R, [C(R9)2]nCON(R)2, [C(R9)2]nN(R9)SO2R, [C(R9)2]nSO2N(R)2, [C(R9)2]nN(R9)SO2OR, [C(R9)2]nOSO2N(R)2, [C(R9)2]nN(R9)SO2N(R)2, [C(R9)2]nC(═NR9)N(R)2, [C(R9)2)nN(R9)C(═NR9)N(R)2, [C(R9)2]nHet;
• any 2 of R1 to R3 or R4 to R6 may together form a ring of 5 to 6 total atoms which may contain 0 to 3 heteroatoms;
• X is NH, NR8;
• f is an integer of from 0 to 3;
• n is an integer of from 0 to 3;
• m is an integer of from 2 to 4;
• p is an integer from 1 to 2;
• R7 is a straight or branched alkyl of 1 to 6 carbons or a carbocycle of 3 to 6 carbons;
• R8 is a straight or branched alkyl of 1 to 6 carbons, a carbocycle of 3 to 6 carbons, (CH2)nPh, or a (CH2)nheterocycle of 5 to 6 atoms containing 1 to 4 heteroatoms and wherein the (R)2 in N(R)2 optionally forms a heterocycle containing the nitrogen, all optionally substituted by F, Cl, Br, OR9, CN, CO2R9, N(R9)2, NR9COR9, CF3, or ═O;
• or an alkyl group bearing polar functionalities, optionally including OH, NH2, CN;
• R1 and R8 may together form a ring of 5 to 6 atoms;
• R is independently H, a straight or branched alkyl of 1 to 6 carbons, (CH2)nPh, or a (CH2)nheterocycle of 5 to 6 atoms containing 1 to 4 heteroatoms and wherein the (R)2 in N(R)2 optionally forms a heterocycle containing the nitrogen, all optionally substituted by F, Cl, Br, OR9, CN, CO2R9, N(R9)2, NR9COR9, CF3, or ═O;
• R9 is independently H, a straight or branched alkyl of 1 to 4 carbons, or phenyl;
• R10 is independently H, a straight or branched alkyl of 1 to 4 carbons, F, Cl, Br, OR9 or N(R9)2;
• R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 may be alkene or alkyne of from 2 to 6 carbon atoms;
• Ar1 and Ar2 are independently phenyl or Het;
• Het is a heterocycle of from 5 to 6 atoms having from 1 to 4 heteroatoms or a fused heterocycle of from 9 to 10 atoms having 1 to 3 heteroatoms
• wherein the heteroatoms are independently N, O or S,