Intravenous formulation of artelinic acid for treatment of severe and complicated malaria
OwnerAi J. Lin, John VanHamont +1inventors
InventorsAi J. Lin, John VanHamont, Wilbur K. Milhous
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Abstract
Chemical entities of artelinic acid-L-lysine salts and their intravenous formulation for treatment of severe and complicated malaria, especially the cerebral malaria, which is fatal if not treated promptly, and method of making an intravenous artelinic acid-L-lysine salt formulation.
Claims17
A composition comprising artelinic acid/L-lysine salt having the following formula:
- 4
An antimalarial formulation comprising:
- artelinic acid/L-lysine salt in solution.
A method of forming an Artelinic Acid/L-lysine intravenous antimalarial formulation comprising:
- a)preparing an artelinic acid/L-lysine salt;
- b)preparing a vehicle solution, said vehicle solution comprising purified L-lysine in normal saline or 5% glucose;
- and
- c)dissolving said artelinic acid/L-lysine salt in said vehicle solution to form said antimalarial formulation.
A method of forming an Artelinic Acid/L-lysine intravenous antimalarial formulation comprising:
- a) purifying L-lysine;
- b) preparing an artelinic acid/L-lysine salt;
- c) preparing a vehicle solution, said vehicle solution comprising purified L-lysine in normal saline or 5% glucose;
- d) dissolving said artelinic acid/L-lysine salt in said vehicle solution to form said antimalaria formulation.
A powdered Artelinic Acid/L-lysine prepared by the process comprising:
- a) dissolving AL/LY salt in solution containing 0.1-0.5% equivalent mole of purified L-lysine,
- b) lyophylization said dissolved AL/LY salt solution to yield powder.
Dependencies are inferred from the claim text.