New nitromethyl ketones, process for preparing them and compositions containing them

A compound of the formula:

• 52
• in which
• A represents C6-C10-aryl or an optionally aromatic three- to ten-membered heterocycle in which one to four ring atoms are identical or different heteroatoms chosen from O, S and N;
• X represents halogen, cyano, C1-C7-alkyl, trifluoromethyl, C2-C7-alkoxy or trifluoromethoxy;
• R1 and R2, which are identical or different, represent a hydrogen atom, a C1-C7-alkyl group, a C1-C12-cycloalkyl group, a trifluoromethyl group, a C1-C7-alkoxy group or R1 and R2 together form an alkylene chain —(CH2)r—, where r is chosen from 2, 3 and 4;
• p is chosen from 0, 1, 2, 3, 4 and 5;
• Z represents a bond, the divalent radical —CO—NH— in which the carbonyl function is linked to R3, the divalent radical —SO2—NH— in which the sulfonyl function is linked to R3, a C2-C7-alkenylene radical, a sulfur atom, the sulfinyl radical or the sulfonyl radical;
• R3 represents a hydrogen atom;
• a halogen atom;
• a tri-(C1-C7-alkyl)silyl group;
• a C1-C7-alkyl group optionally substituted with one or more identical or different Y radicals;
• a C6-C10-aryl group optionally substituted with one or more identical or different Y radicals;
• a C6-C1-aryloxy group optionally substituted with one or more identical or different Y radicals;
• a C3-C12-cycloalkyl group optionally substituted with one or more identical or different Y radicals;
• an optionally aromatic three- to ten-membered heterocycle in which one to four ring atoms are identical or different heteroatoms chosen from O, S and N, the heterocycle being optionally substituted with one or more identical or different Y radicals, or R3 represents indanyl, 1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl, 1,3-benzodioxolyl, 2-oxopiperidinyl or 2-[(4-nitromethylcarbonyl-3-chlorophenyl)aminocarbonyl]-1-(phenyl)ethyl;
• Y represents a halogen atom, C1-C7-alkyl, C1-C7-alkoxy, trifluoromethyl, carboxy, carbamoyl, (C1-C7)alkylcarbamoyl, di-(C2-C7)alkylcarbamoyl, C-c,-alkoxycarbonyl, amino, C1-C7-alkylamino, di-(C1-C7)-alkylamino, nitro, cyano, hydroxy, trifluoromethoxy, C3-C12-cycloalkyl, sulfo, C1-C7-alkylthio, C1-C7-alkylsulfinyl, C1-C7-alkylsulfonyl, C2-C8-alkylcarbonyl, C2-C8-alkylthiocarbonyl, C2-C8-alkylcarbonylamino, or C6-C10-aryl;
• E represents a divalent radical chosen from:
• (i) —CO—NR4—, in which the carbonyl group is linked to —(CR1R2)p— and R4 represents the radical (CH2)q—R5 where q is chosen from 0 and 1;
• and where R5 represents a hydrogen atom;
• a C1-C7-alkyl group, a C6-C10-aryl group or an optionally aromatic three- to ten-membered heterocycle in which one to four ring atoms are identical or different heteroatoms chosen from O, N and S;
• or R5 and R3 together form a bond;
• (ii) —SO2—NR4— in which the sulfonyl group is linked to —(CR1R2)p— and R4 is as defined above;
• (iii) —NR4— in which R4 is as defined above;
• (iv) —CH═N— in which the nitrogen atom is linked to A;
• and
• (v) an oxygen atom;
• n represents 0 or 1;
• on the condition that -A(X)-(E), —(CR1R2)p-Z-R3 does not represent halophenyl, methylphenyl, dichlorophenyl, dimethylphenyl, 4-ethoxy-2-methylaminophenyl, methylindolyl, dimethylindolyl, 2-hydroxyphenyl substituted with a group X, 2-methoxyphenyl substituted with a group X and optionally substituted 2-fluorophenyl as defined above, and
• on the condition that when A represents pyridyl, X represents methyl and n is equal to 1, E does not represent —NR4—,
• and addition salts thereof with pharmaceutically acceptable bases.