Method for treatment of tumors using nordihydroguaiaretic acid derivatives
AssigneeThe John Hopkins University
InventorsRu Chih C. Huang, Jonathan D. Heller, Chih-Chuan Chang
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Abstract
Use of nordihydroguaiaretic derivatives to suppress CDC-2 and survivin, stimulate apoptosis, and treat tumors.
Claims21
A method of inhibiting survivin production in a eukaryotic cell cycle comprising administering an effective amount of a compound of formula
- 3
- wherein R1, R2, R3 and R4 independently represent —OH, OCH3,—O(C═O)CH3, or an amino acid residue, but are not each —OH simultaneously.
The method of claim 3 wherein said cell is a mammalian cell.
The method of claim 4 wherein said cell is a human cell.
A method of stimulating apoptosis in a cell expressing CDC-2 and survivin comprising administering an effective amount of a compound of formula
- 4
- wherein R1, R2, R3 and R4 independently represent —OH, OCH3,—O(C═O)CH3, or an amino acid residue, but are not each —OH simultaneously.
A method for treating a tumor, said method comprising application of an effective amount of a compound of formula
- 5
- wherein R1, R2, R3 and R4 independently represent —OH, OCH3,—O(C═O)CH3, or an amino acid residue, but are not each —OH simultaneously.
Dependencies are inferred from the claim text.