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US 2003/0171414 A1Published application
New salt hydrates
AssigneeNovartis AG
InventorErwin Ernst Marti
Life of this patent
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Abstract
The invention relates to new forms of salts of valsartan or crystalline, also partly crystalline and amorphous salts of valsartan, the respective production and usage, and pharmaceutical preparations containing such a salt.
Claims24
A salt of valsartan selected from (i) polymorphs of the tetrahydrate,
- (ii) polymorphs of the trihydrate,
- (iii) the monohydrate, and
- (iv) the di-(calcium salt of valsartan) pentahydrate,
- in each case of the calcium salt of valsartan, and the anhydrate thereof;
- and selected from
- (i) a polymorphic form of the hexahydrate,
- (ii) the trihydrate, and
- (iii) the monohydrate
- in each case of the magnesium salt of valsartan, and the anhydrate thereof.
6 more elements
The pentahydrate of the di-(calcium salt of valsartan) according to claim 12, characterised by an x-ray powder pattern taken with a Guinier camera comprising the following interlattice plane intervals:
- d in [Å]:
- 15.5±0.3, 11.5±0.2, 9.4±0.2, 9.04±0.1, 6.46±0.05, 6.09±0.05, 5.82±0.05, 5.16±0.05, 4.48±0.05, 3.60±0.05.
The amorphous calcium salt of valsartan according to claim 14, characterised by
- (i) a water content of 9±2%
- (ii) a glass transition of 143±20° C.
- (iii) no melting point
- (iv) no enthalpy of fusion.
1 more element
Dependencies are inferred from the claim text.