Novel delta dicarbonyl compounds and methods for using the same
AssigneeBeacon Laboratories, a Delaware corporation
InventorsHsuan-Yin Lan-Hargest, Norbert L. Wiech
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Abstract
Amidomethyl esters, carbonylmercaptomethyl esters, keto-containing esters, amidomethyl thioesters, amidomethyl amides, and methylene dithioesters are disclosed. The novel compounds have two carbonyl groups connected by a linking moiety having an oxygen, sulfur or nitrogen attached to a methylene group, to which is further attached a sulfur, nitrogen or CH2 group. Methods of treating illnesses and conditions, such as cancer, hemological disorders, inherited metabolic disorders and others, using these compounds are also disclosed.
Claims18
A compound having the formula (1):
- 2
- wherein X is selected from the group consisting of oxygen, sulfur and N(R);
- wherein Y is selected from the group consisting of sulfur, N(R), and CH2;
- wherein R is either H or CH3;
- wherein R1 and R2 are the same or different and have the general formula (2);
- —(CH2)o—(R3)p—(CH2)q—(R4)r—(CH2)s-Z (2)
- wherein R3 and R4 are the same or different and are selected from the group (CH═CH), (C≡C), sulfur and oxygen;
- wherein Z is selected from the group consisting of hydrogen and substituted or unsubstituted aryl, heteroaryl, cycloalkyl having the general formula CnH2n-1 and alkoxy;
- wherein n is 3 or greater;
- and
- wherein o, p, q, r and s are the same or different and are each between 0 and 10.
A method for treating an illness in a patient comprising administering to said patient an effective amount of a compound having the formula:
- 3
- wherein X is selected from the group consisting of oxygen, sulfur and N(R);
- wherein Y is selected from the group consisting of sulfur, N(R), and CH2;
- wherein R is either H or CH3;
- wherein R1 and R2 are the same or different and having the general formula (2);
- —(C2)o—(R3)p—(CH2)q—(R4)r—(CH2)s-Z (2)
- wherein R3 and R4 are the same or different and are selected from the group (CH═CH), (C≡C), sulfur and oxygen;
- wherein Z is selected from the group consisting of hydrogen and substituted or unsubstituted aryl, heteroaryl, cycloalkyl having the general formula CnH2n-1 and alkoxy;
- wherein n is 3 or greater;
- wherein o, p, q, r and s are the same or different and are each between 0 and 10.
Dependencies are inferred from the claim text.