Medicinal compositions containing propenone derivatives
OwnerAkihiko Satoinventor
Life of this patent
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Abstract
A combination of an integrate inhibitor with an anti-retrovirus active substance and medical compositions containing the same as the active ingredients are found.
Claims12
An anti-retrovirus composition which contains as active ingredients a compound represented by the formula (I):
- A-C(═O)—CH═C(OH)—B wherein A is optionally substituted heteroaryl;
- B is optionally substituted heteroaryl or optionally substituted aryl;
- provided that cases wherein A and/or B are optionally substituted indol-3-yl are excluded;
- a tautomer, a prodrug, a pharmaceutically acceptable salt, or a solvate thereof, and one or more different type of anti-retrovirus active substances.
A pharmaceutical composition which contains a compound, which exhibits an activity promoting anti-retrovirus activity of anti-retrovirus active substance, and is represented by the formula (I):
- A-C(═O)—CH═C(OH)—B wherein A is optionally substituted heteroaryl;
- B is optionally substituted heteroaryl or optionally substituted aryl;
- provided that cases wherein A and/or B are optionally substituted indol-3-yl are excluded;
- a tautomer, a prodrug, a pharmaceutically acceptable salt, or a solvate thereof.
A method for treating or preventing retrovirus infection, which comprises a simultaneous or continuous administration of the compound represented by the formula (I):
- A-C(═O)—CH═C(OH)—B wherein A is optionally substituted heteroaryl;
- B is optionally substituted heteroaryl or optionally substituted aryl;
- provided that cases wherein A and/or B are optionally substituted indol-3-yl are excluded;
- a tautomer, a prodrug, a pharmaceutically acceptable salt, or a solvate thereof, and one or more different type of anti-retrovirus active substances.
Use of a compound represented by the formula (I):
- A-C(═O)—CH═C(OH)—B wherein A is optionally substituted heteroaryl;
- B is optionally substituted heteroaryl or optionally substituted aryl;
- provided that cases wherein A and/or B are optionally substituted indol-3-yl are excluded;
- a tautomer, a prodrug, a pharmaceutically acceptable salt, or a solvate thereof, and one or more different type of anti-retrovirus active substance for preparation of a medicament for treating and preventing retrovirus infection.
Dependencies are inferred from the claim text.